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research Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

52 citations , January 2003 in “Journal of Investigative Dermatology”

This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.

Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase

research Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase

5 citations , January 2021 in “Biomedicine & Pharmacotherapy”

This study suggests that policosanol may prevent androgenetic alopecia in mice by regulating hormone levels and suppressing premature hair follicle entry into the regression phase.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22

52 citations , May 2015 in “PLOS Genetics”

This study found that the microRNA miR-22 is a key regulator of the hair cycle, influencing hair loss by promoting the transition from growth to rest phases and repressing keratinocyte differentiation.

research Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

173 citations , September 2011 in “Journal of Investigative Dermatology”

IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.

A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

research A Murine Model for Inducing and Manipulating Hair Follicle Regression (Catagen): Effects of Dexamethasone and Cyclosporin A

124 citations , August 1994 in “Journal of Investigative Dermatology”

This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.

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Community Join

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community Regression? Has anyone experienced this?

in Progress Pictures 46 upvotes 1 year ago

The user is experiencing increased hair shedding and is concerned about regression despite consistent use of finasteride, minoxidil, and other treatments. The consensus is that this is likely a temporary shedding phase, and adjustments to the dermarolling frequency are suggested.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

324 upvotes 7 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

4 upvotes 1 year ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

community Insane regression after hyper-responding (17M) AMA

in Progress Pictures 137 upvotes 1 year ago

A 17-year-old experienced significant hair loss after switching from topical to oral minoxidil and adding finasteride. The recommendation is to return to topical minoxidil and continue with finasteride or consider dutasteride.

community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

in Research/Science 5 upvotes 1 year ago

Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

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Learn

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learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Overview

learn Beta Polypeptide

learn Stem Cell Factor

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn oleic acid

How does Oleic Acid support hair follicle strength and growth? Oleic acid strengthens hair follicles by enhancing hydration and reducing inflammation.

learn zinc PCA

Why is zinc important for preventing hair loss and supporting hair follicle function? Zinc is crucial for hair follicle health, supporting growth and repair processes.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Scalp micropigmentation does not damage existing hair or follicles.

learn Osteopontin

What role does Osteopontin play in protecting and repairing hair follicles? Osteopontin protects and repairs hair follicles by signaling cells to survive and recover.

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