This article discusses the potential of using ultrasonography to assess hair and follicular pathology non-invasively and reports no new clinical results.
July 2025 in “Journal of Oncology Research and Therapy”
This study found that the effectiveness of scalp cooling in preventing chemotherapy-induced alopecia in early-stage breast cancer patients depends on the integrity of the follicular pigmentary unit, particularly consistent melanosome quantity.
24 citations
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November 2019 in “Experimental Dermatology”
This review synthesizes current research on PPAR-γ signaling in hairfollicle biology and its potential role in treating hair growth disorders like scarring alopecia and hirsutism, but reports no new clinical results.
15 citations
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February 2015 in “Cell & tissue research/Cell and tissue research”
This review examines the role of P-cadherin in skin and hair biology, emphasizing its importance in human hair growth, cycling, and pigmentation, and reports no new research findings.
Hair regeneration and follicle cloning are considered far from being feasible, with current treatments like finasteride, minoxidil, and hair transplants expected to remain dominant for the next 15-20 years. Some are hopeful that AI advancements might accelerate progress, but many remain skeptical about significant breakthroughs in the near future.
Hair loss treatments discussed include microneedling, minoxidil, tretinoin, finasteride, dutasteride, pumpkin seeds, saw palmetto, and scalp massage. The consensus is that finasteride or dutasteride is necessary for significant regrowth, while other methods may only slow hair loss.
Ultrasound imaging can non-invasively detect active and inactive hairfollicles, inflammation, and fibrosis, potentially reducing unnecessary biopsies. It may help assess hair growth potential and diagnose scalp issues, but some users believe in trying treatments regardless of ultrasound results.
PP405 is ineffective for miniaturized, fibrosed hairfollicles in androgenetic alopecia. AMP303 may activate hairfollicle stem cells, but minoxidil and finasteride are still the main treatments.
PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hairfollicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.