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research External light activates hair follicle stem cells through eyes via an ipRGC–SCN–sympathetic neural pathway

61 citations , June 2018 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that light stimulation of intrinsically photosensitive retinal ganglion cells in the eyes can activate hair follicle stem cells through a neural circuit involving the sympathetic nervous system.

research SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice

38 citations , July 2020 in “EMBO journal”

In this study, researchers found that SIRT7 activates quiescent hair follicle stem cells to promote hair growth in mice by triggering the telogen-to-anagen cycle transition, with potential implications for age-related hair loss.

research 1298 External light activates hair follicle stem cells through eyes via the ipRGC-SCN-sympathetic neural circuit

April 2018 in “Journal of Investigative Dermatology”

This study found that external light can rapidly activate hair follicle stem cells in animals via a retinal light-sensing pathway linked to the central and autonomic nervous systems.

research LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells

12 citations , August 2020 in “Frontiers in Genetics”

This study suggests that the long noncoding RNA H19 helps dermal papilla cells maintain their hair follicle-inducing ability by activating the Wnt signaling pathway, potentially offering a therapeutic target for androgenetic alopecia.

research Low‐level laser activates Wnt/β‐catenin signaling pathway‐promoting hair follicle stem cell regeneration and wound healing: Upregulate the expression of key downstream gene Lef 1

2 citations , June 2024 in “Skin Research and Technology”

This study found that low-level laser stimulation activates the Wnt signaling pathway, promoting hair follicle stem cell regeneration and accelerating wound healing.

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Community Join

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community Molecule PP405: A Research Team Backed By Google Ventures Has Discovered One Of The Most Promising Solutions For Hair Loss To Date

in Research/Science 479 upvotes 1 year ago

PP405 is a promising new treatment for hair loss that activates dormant stem cells in hair follicles, potentially bypassing the effects of DHT. It is currently in phase 2 trials and could be available between 2027 and 2030, but it is not considered a definitive cure.

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 2 years ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community Keratin microspheres - breakthrough

14 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community TDM-105795 phase 2 results are in!

27 upvotes 2 years ago

TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

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Learn

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learn Stem Cell Factor

How does stem cell factor help activate dormant hair follicles? Stem cell factor activates dormant hair follicles by signaling through the c-Kit receptor.

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn SCUBE3

What do clinical trials say about the safety and effectiveness of SCUBE3 for hair regrowth? No clinical trial of SCUBE3 for hair regrowth has been registered on ClinicalTrials.gov or published, so there is no human safety or effectiveness data. The evidence is limited to one 2022 laboratory and mouse study reporting that SCUBE3 activates hair follicle stem cells through TGF-beta signalling.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn GHK-Cu

a copper peptide showing promise in both regrowth and reversing gray hair

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Ketoconazole

antifungal with some anti-androgenic benefits, often used as a shampoo

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn oleic acid

How does Oleic Acid support hair follicle strength and growth? Oleic acid strengthens hair follicles by enhancing hydration and reducing inflammation.

learn zinc PCA

Why is zinc important for preventing hair loss and supporting hair follicle function? Zinc is crucial for hair follicle health, supporting growth and repair processes.

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Clinics

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All 38 clinic results →

Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas