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research The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles

35 citations , February 2019 in “Cell Communication and Signaling”

This study found that BMP6 and Wnt10b competitively regulate the transition between hair follicle growth phases, offering new insights into hair follicle cycling and potential hair loss treatments.

research UNRAVELING THE POTENTIAL OF NATURAL BIOACTIVES IN COMBATING HAIR LOSS AND SCALP DISORDERS

January 2024 in “Editora Científica Digital eBooks”

This study conducted an integrative review of bioactive substances and their effectiveness in controlling hair loss and scalp disorders, evaluating their potential to restore hair cycle balance and strengthen hair strands, while identifying knowledge gaps and opportunities for future research.

research Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors

322 citations , January 1997 in “Thrombosis and Haemostasis”

This review discusses factors influencing angiogenesis, focusing on vascular permeability factor as a key inducer and thrombospondin as a notable inhibitor, and recommends exploring molecular mechanisms for therapeutic interventions.

research The role of the microbiome in scalp hair follicle biology and disease

73 citations , April 2019 in “Experimental Dermatology”

This review explores the hair follicle microbiome's interaction with the immune system, discussing its potential clinical implications for scalp health and disease but reports no new clinical results.

research Cholesterol homeostasis in hair follicle keratinocytes is disrupted by impaired ABCA5 activity

June 2023 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

In this study, researchers found that knockdown of ABCA5 in primary human hair follicle keratinocytes disrupted cholesterol homeostasis and transportation, suggesting its potential role in hair growth disorders by affecting intracellular cholesterol compartmentalization and LXR-mediated transcriptional activity.

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Community Join

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community You will lose hair if your prostaglandins aren't in balance

56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Sudden dutasteride and OM shed after 1.5 yrs

33 upvotes 1 month ago

The user experienced significant hair shedding after 1.5 years on dutasteride and oral minoxidil, possibly due to a shedding cycle or lifestyle changes like nicotine use and creatine. Opinions vary on whether creatine contributes to hair loss, with some attributing shedding to synchronized hair cycles or genetic factors.

community Increased Coffee intake resulted in massive shed

17 upvotes 1 year ago

Increased coffee intake might be linked to hair shedding, but the cause is unclear. The user is on finasteride and has increased water intake, possibly affecting electrolyte balance.

community Finasteride is Good for Heart Health!

in Research/Science 119 upvotes 2 years ago

Finasteride, a hair loss and prostate drug, may also benefit heart health. Some users discuss the potential negative effects of DHT on the heart and the balance between hair loss treatments and heart health.

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Learn

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learn Follistatin

Protein that blocks activin, a growth-regulating signal

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
When will I see new hair growth after a hair transplant? New hair growth usually starts 2-4 months after a hair transplant.

learn Cyproterone

How long does it take for cyproterone to work on hair loss? There is no reliable published figure for how fast cyproterone works on hair loss: the hair cycle means nothing shows for months, the one randomised trial assessed women at twelve months, and community reports range from about six months to two years — with some people seeing no change at all.

learn Rapamycin

Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.

learn SCUBE3

Signalling protein made in the hair follicle

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Peppermint

herb and oil thought to stimulate skin and hair

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Clinics

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All 41 clinic results →

Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas