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community My progression as a female with female hair loss

48 upvotes 1 year ago

A 30-year-old female shares her positive progress with hair regrowth using topical minoxidil and vitamins, after experiencing hair loss since her early 20s. She mentions using a product with a natural DHT blocker and emphasizes the importance of checking vitamin and iron levels.

community 2nd shed Update: Lost everything and still losing like crazy.

in Update 176 upvotes 1 year ago

The user experienced significant hair loss after initially successful treatment with minoxidil and finasteride, leading to a second shedding phase. They are considering switching to oral minoxidil for convenience and are advised to continue treatment despite the shedding, as regrowth is expected.

community Anyone have experience with natural DHT blockers?

7 upvotes 2 years ago

The conversation is about using natural DHT blockers like pumpkin seed oil and saw palmetto extract for hair loss. The user has been using minoxidil, derma rolling, vitamin D, and biotin but is considering finasteride next.

community Natural DHT Blockers instead of fin

4 upvotes 6 years ago

The conversation discusses using natural DHT blockers like saw palmetto, beta sitosterol, pumpkin seed oil, pygeum africanum bark, and nettle root as alternatives to finasteride for hair loss, with mixed opinions on their effectiveness. Some users report minimal improvement with natural options and better results with finasteride or dutasteride, despite concerns about potential side effects.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn PP405

Is PP405 a peptide that protects follicles from DHT? PP405 is not a peptide and does not block DHT: it is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, aimed at waking dormant follicles. Its registered Phase 2 trial (NCT06393452) measured safety and tolerability in 78 adults with pattern hair loss; it is not approved and not for sale.

learn procapil

Does Procapil block DHT without affecting hormones? What the evidence shows Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Nanoxidil

learn Dutasteride

A stronger DHT blocker than finasteride, approved for hair loss only in South Korea and Japan and off-label elsewhere, with the same class of side effects and a much longer washout.

Dutasteride: What if I just want to grow back some hair without taking pills every day? There is no approved topical dutasteride; it exists only as pharmacy-compounded preparations and small studies, so its effectiveness and long-term safety are not established.

learn Exosomes

What does Fluridil do on the scalp, and how does it block the DHT hormone? Fluridil is a topical anti-androgen sold in some European countries. One small 2002 trial led by its developer reported more hairs in the growth phase; it is not FDA-approved and the evidence is limited.

learn TDM-105795

What is TDM-105795, and why is it being studied as a potential product for hair loss and hair growth support? TDM-105795 is an experimental topical drug that has been tested only in men with androgenetic alopecia, in two Phase 1 studies and one 16-week Phase 2 trial of 71 men. It is not approved, and no peer-reviewed trial results have been published.

learn H3-Grow+ Complex™

learn GT20029

Investigational compound designed to degrade androgen receptors in the scalp; not approved or sold anywhere.

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Research

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research Hair Growth-Promoting Effects of a Multi-Targeted Cosmetic Formulation Containing PYGL, DP2, and 15-PGDH Inhibitors Developed Using AI-Based DeepZema® in Androgenetic Alopecia: A 24-Week Randomized Controlled Trial

April 2026 in “Cosmetics”

In this randomized, double-blind, placebo-controlled trial, researchers found that a multi-targeted cosmetic formulation containing TrinogeniX™ significantly increased hair density and thickness in individuals with androgenetic alopecia without adverse effects, suggesting it as a potential safe and effective treatment option.

research It's Not “Like Growing Grass”

May 2012 in “Scientific American”

Blocking a compound called prostaglandin D₂ might help treat hair loss.

research Phytotherapy in Trichology: A Review

December 2025 in “Brazilian Journal of Hair Health”

This review highlights that natural DHT blockers like saw palmetto and pumpkin seed oil show promise in managing androgenetic alopecia, though clinical data varies, and further research is needed to confirm their efficacy and safety in comparison to conventional pharmaceuticals.

research Concomitant immobilization of androgen receptors and 5α- reductase in androgenic alopecia

January 2025 in “International Journal of Dermatology Research”

In this study, a herbal preparation inhibited the conversion of testosterone to DHT and its binding on hair roots in vitro, suggesting potential as an alternative treatment for androgenic alopecia without the safety concerns associated with finasteride.

research Human placental extract exerts hair growth-promoting effects through the GSK-3β signaling pathway in human dermal papilla cells

20 citations , August 2015 in “International Journal of Molecular Medicine”

This study found that human placental extract promoted hair growth and influenced cellular pathways in vitro and rat models, suggesting potential for future hair loss treatments.

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Clinics

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