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research Plasticity of GABAergic Inhibition

January 2014 in “eScholarship (California Digital Library)”

This article discusses the plasticity of δ-GABAARs during altered neurosteroid production and its effects on neuronal network function, with potential therapeutic strategies proposed for several neurological and psychiatric disorders.

research Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus

19 citations , September 2006 in “Journal of Neurophysiology”

In this study, researchers found that after reducing GABAergic inhibition in rats' auditory midbrain, the brain quickly compensates by increasing local neurosteroid synthesis to maintain balance in neural circuits.

research Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA_AReceptors

248 citations , December 2011 in “Journal of Neuroscience”

This study demonstrated that stress-derived neurosteroid THDOC shifts from inhibiting to activating the HPA axis under stress, presenting potential therapeutic targets for stress-related disorders.

research Finasteride treatment and neuroactive steroid formation.

9 citations , January 2009 in “PubMed”

This study found that finasteride treatment in men with benign prostate hyperplasia significantly altered steroid hormone profiles and may contribute to depressive symptoms by affecting neuroactive steroid levels.

research Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD

59 citations , November 2018 in “Psychoneuroendocrinology”

This study suggests that cerebrospinal fluid levels of the neurosteroids allopregnanolone and pregnanolone correlate negatively with PTSD and negative mood symptoms, with potential sex-specific differences in synthesis enzyme blocks.

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community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress)

in Progress Pictures 35 upvotes 1 year ago

A 22-year-old resumed using finasteride, minoxidil, and a 0.5mm dermaroller after stopping for two years, experiencing positive results and improved mood. The discussion includes debates on the effects of finasteride on neurosteroids and the optimal dermaroller needle length for hair regrowth.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 2 years ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Intermittent Finasteride dosing for reduction of side effects?

6 upvotes 7 years ago

Intermittent finasteride dosing, like taking it every third day, may reduce side effects while still lowering DHT levels. Users report side effects such as brain fog and weaker erections, which often subside after stopping the drug.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

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