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research Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging

March 2026 in “Ageing Research Reviews”

This review highlights the complex interplay between intrinsic and extrinsic factors influencing skin aging, emphasizing the need for advanced human-specific models to study aging mechanisms and develop new therapies.

research Optimization of hair follicle spheroids for hair-on-a-chip

January 2024 in “Biomaterials Science”

This study explored hair follicle research by co-culturing dermal papilla cells, keratinocytes, and endothelial cells in spheroids, finding elevated hair growth factor expression and potential for creating skin equivalents with hair through a "hair-on-a-chip" approach.

research 710 Use of mass spectrometry imaging and a full thickness 3D skin equivalent for evaluation of percutaneous absorption

April 2017 in “Journal of Investigative Dermatology”

This study found that retinoic acid and a retinol complex formulation showed different permeation and compound localization in a skin equivalent model, with unique lipid changes observed with only the retinol formulation.

research Feasibility of repairing full-thickness skin defects by iPSC-derived epithelial stem cells seeded on a human acellular amniotic membrane

23 citations , May 2019 in “Stem cell research & therapy”

This study found that combining a human acellular amniotic membrane with iPSC-derived epithelial stem cells effectively repaired skin defects and promoted hair follicle formation in nude mice.

research Influence of donor sources and culture media on the histo-morphological quality of human artificial skin models

January 2018 in “Online Publication Service of Würzburg University (Würzburg University)”

This study found that donor age and culture medium significantly impact the quality of human full-thickness skin models, with implications for their use as animal model alternatives in research.

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Community Join

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community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Story time! The Great Unbalding (PP405)

230 upvotes 11 months ago

PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

community Finasteride won’t make all your problems go away

in Finasteride/Dutasteride 323 upvotes 2 years ago

A user shared that while finasteride improved their hair, it didn't solve all their insecurities, suggesting that self-acceptance is key. Others in the conversation expressed varying opinions, with some feeling that finasteride significantly boosted their confidence and quality of life, while others acknowledged it as a solution to hair loss but not a cure-all for other personal issues.

community The Fear of Oral Minoxidil is Overblown

272 upvotes 1 year ago

Low-dose oral minoxidil is a safe and effective hair loss treatment with fewer side effects than previously feared. Users often prefer it over topical minoxidil for better results, though some experience side effects like increased body hair and cardiovascular issues.

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Clinics

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Experts

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SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin