August 2026 in “Advanced Science” This study reported that activating the WNT5A-ATF3-FOSB axis in mice inhibited androgenetic alopecia progression, suggesting this pathway as a potential therapeutic target for hair loss disorders.
January 2022 in “JPK Jurnal Proteksi Kesehatan” This study found that the ethanol extract of mangkokan leaf (Polyscias scutellarium) demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, with higher concentrations showing greater inhibition zones, particularly against Staphylococcus aureus.
30 citations
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August 2021 in “Oncogene” This study reports that miR-22 promotes cancer progression and metastasis by maintaining Wnt/β-catenin signaling and cancer stem cell function.
70 citations
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August 2006 in “Cancer Research” This study found that inhibiting AP-1 activity in mice modified tumor development, leading to transdifferentiation between squamous and sebaceous tumors, with molecular analysis suggesting AP-1's role in maintaining tumor cell identity.
This study found that inhibiting AP-1 transcription factors in mice causes squamous tumors to transform into sebaceous tumors and regulates tumor cell lineage.