This study reports that melatonin influenced HaCaT cell proliferation, with high concentrations reducing DNA synthesis and low concentrations enhancing it after 24 hours.
4 citations
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April 1986 in “Cancer Letters” This study found no significant difference in glutathione-S-epoxide transferase activity in hair follicles between smokers and non-smokers, suggesting this enzyme's levels may not indicate polycyclic aromatic hydrocarbon-related cancer risk.
5 citations
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January 2018 This study optimized a screening assay to identify molecules that inhibit or enhance TRPM5 ion channel activity, which may have implications for treating dysfunctions linked to cardiac arrhythmias and diabetes.
105 citations
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May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that activation of the TRPV3 ion channel inhibits human hair growth by affecting hair follicles and outer root sheath keratinocytes.
10 citations
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November 2018 in “Genetics in medicine” This study identified a genetic variant in the CTS6 gene associated with a hypotrichosis syndrome, emphasizing the significant role of cystatin M/E in hair and skin health.
