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In this study, 4 MHz monopolar radiofrequency treatment significantly improved facial wrinkles in 62 patients, with a 93.55% effectiveness rate and minimal adverse reactions like mild erythema and edema observed 90 days post-treatment.

This study identified sex-specific determinants for facial wrinkles, finding that age is the strongest factor and that lifestyle influences like smoking, alcohol use, and skin color differentially affect wrinkling in men and women.

In this study, the combination of ECM-C with microneedle and radiofrequency treatments improved periorbital wrinkles, skin elasticity, and thickness more effectively than ECM-C with microneedles alone, but subjective evaluations showed no significant differences.

In this study, a 6-month randomized controlled trial with postmenopausal women reported that supplementing with soy protein isolate with isoflavones led to significant improvements in skin hydration and reduced wrinkles and facial pigment intensity, but did not affect sebum production.

This review outlines various clinical methods for assessing ageing skin and discusses their application in supporting the efficacy claims of anti-ageing treatments, but it reports no new clinical results.