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Glossary Estrogen

group of hormones regulating female reproductive system and traits

Estrogen, also spelled oestrogen, is a group of hormones primarily responsible for the development and regulation of the female reproductive system and secondary sexual characteristics. It plays a crucial role in the menstrual cycle, pregnancy, and bone health, and is also present in smaller amounts in males, where it helps regulate certain functions of the reproductive system and maintain bone density.

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Research

5 / 1000+ results

research Androgen receptor in rat liver: Characterization and separation from a male-specific estrogen-binding protein

24 citations , January 1989 in “Archives of biochemistry and biophysics”

This study found that androgen binding in male rat livers involves specific androgen receptors, which decrease with castration and are inducible in female livers with testosterone.

research New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature

19 citations , December 2021 in “Endocrine Reviews”

This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.

research A Review of Gender-Affirming Hormone Therapy for Transgender and Gender Diverse Adults in South Korea

4 citations , January 2022 in “Journal of Menopausal Medicine”

This review discusses gender-affirming hormone therapies in South Korea, detailing the available treatment regimens and associated side effects, but reports no new clinical findings.

research Testosterone therapy for sexual dysfunction in postmenopausal women

46 citations , January 2008 in “Climacteric”

Randomized trials reported that testosterone therapy improved sexual function in postmenopausal women with hypoactive sexual desire disorder, particularly those who had undergone oophorectomy, with reversible and well-tolerated side effects.

research The use of testosterone after menopause

5 citations , June 2004 in “The Journal of The British Menopause Society”

This study found that testosterone therapy can enhance sexual satisfaction and mood in surgically menopausal women on oestrogen, though ongoing monitoring and research are needed to assess long-term safety and effects in other groups.

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Community Join

5 / 799 results

community Well… I Did It. Estrogen Saved My Hairline

in Transgender 732 upvotes 1 year ago

OP transitioned and used Spironolactone, Estradiol Valerate, Minoxidil, and dermarolling, resulting in significant hair regrowth. They advise this method may not be suitable for cis men.

community Losing ground on 3x a week finasteride

in Finasteride/Dutasteride 3 upvotes 8 months ago

The user is experiencing hair loss despite using finasteride three times a week due to side effects and is considering alternatives like topical finasteride, estrogen blockers, or dutasteride. They are also interested in potential treatments like GT20029 and pyrilutamide.

community 2.5mg Dut/RU/minoxidil can't counter 15mg Testosterone..

in Finasteride/Dutasteride 6 upvotes 1 year ago

Despite using Dutasteride, RU58841, and Minoxidil, hair loss continues due to low testosterone levels from taking 15mg of testosterone weekly, which may not produce enough estrogen. Increasing testosterone dosage and stabilizing hormone levels might help address the issue.

community Give me courage, friends! / Is finasteride response correlated with aggressiveness of hair loss?

in Finasteride/Dutasteride 6 upvotes 3 years ago

The user has been using topical finasteride for seven months and minoxidil for three years, with added tretinoin gel for ten months, and is experiencing continuous shedding without signs of regrowth. They are questioning if the amount of shedding is normal at this stage of treatment and if there's a correlation between finasteride response and the rate of hair loss.

community After about 3 months of 2mg Estradiol (Sublingual) and 2.5mg Minox (Oral) daily

in Progress Pictures 160 upvotes 9 months ago

A person transitioning is using 2mg sublingual estradiol and 2.5mg oral minoxidil daily for hair regrowth, noting significant progress in three months. They plan to increase estrogen dosage and consider adding dutasteride, discussing the effects and challenges of transitioning.

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Learn

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learn Ethinylestradiol

learn Ethynylestradiol

learn Overview

learn Alfatradiol

Alfatradiol: What does a form of estrogen have to do with hair loss in men? Alfatradiol (17α-estradiol) is a prescription topical hormone, licensed for androgenetic alopecia in Germany but not FDA-approved. The controlled trial evidence is in women, where it produced stabilisation rather than regrowth and was outperformed by minoxidil; no comparable placebo-controlled trial in men appears to have been published.

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Experts

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SMP Specialist
David Gellei
Melbourne, VIC, Australia

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David Gellei