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research In this Issue

2 citations , April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that vitamin D receptor presence is vital for normal hair growth in mice, as shown by vitamin D receptor-null mice developing alopecia, while transgenic expression of human vitamin D receptor in these mice restored normal hair growth.

research Frontal fibrosing alopecia: Iatrogenic endocrine disruption

May 2015 in “Journal of the American Academy of Dermatology”

Certain drugs and supplements may contribute to hair loss in the frontal hairline in older women.

research [Acitretine].

1 citations , September 2001 in “PubMed”

This review discusses the effectiveness and risks of acitretin in treating various skin conditions, highlighting its teratogenic potential and the necessary precautions for its use.

research Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

53 citations , October 2014 in “Free radical biology & medicine”

This study found that oxidative damage is present in the mitochondria of PolG mice, which exhibit premature aging-like phenotypes due to mitochondrial dysfunction.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

75 citations , January 2014 in “Korean Journal of Urology”

This review discusses the adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, on sexual, psychological, and vascular health, emphasizing the need for physicians to inform patients of these risks.

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Community Join

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community Attention Finasteride / Dutasteride and Your liver

374 upvotes 1 year ago

Finasteride may cause elevated liver enzymes, potentially leading to liver issues, though this is rare. Users should monitor liver function and consider topical alternatives if liver sensitivity occurs.

community liver problem from finasteride/dutasteride

13 upvotes 3 years ago

The conversation discusses liver issues potentially linked to long-term use of finasteride and dutasteride, with users sharing similar experiences of elevated liver enzymes, high cholesterol, and other health concerns. The consensus suggests stopping the medication and consulting a healthcare professional for proper diagnosis and treatment.

community A warning to those using or thinking about using Dutasteride – Follow-up

18 upvotes 5 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community 4 Months on Dut+Topical Min barely any progress.

in Is this regrowth? 31 upvotes 1 month ago

The user has been using dutasteride every other day and topical minoxidil for 4 months with minimal progress in hair regrowth, though shedding has reduced. Suggestions include switching to oral minoxidil due to possible enzyme issues and considering a hair transplant for more effective results.

community Taking one for the Team and trying out the Carbonic Acid Shampoo from the YouTube Ad.

in Product 5 upvotes 5 years ago

A user tried a Carbonic Acid shampoo to improve Minoxidil absorption for hair loss, but others suggested it might be ineffective due to enzyme issues. Alternatives like tretinoin and other Minoxidil solutions were discussed as potentially more effective options.

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Learn

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learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

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