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GlossaryEGFR inhibitors

block cell growth signals to treat certain cancers

EGFR inhibitors, also known as Epidermal Growth Factor Receptor inhibitors, are a class of drugs that block the activity of the EGFR, a protein on the surface of cells that helps them grow and divide. By inhibiting this receptor, these drugs can slow down or stop the growth of certain types of cancer cells that rely on EGFR for proliferation. They are commonly used in the treatment of cancers such as non-small cell lung cancer and colorectal cancer.

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Cutaneous and Mucosal Side Effects of New Anticancer Drugs: EGF-R Inhibitors, Tyrosine Kinase Inhibitors, and Mitotic Spindle Stabilizers

research Cutaneous and Mucosal Side Effects of New Anticancer Drugs: EGF-R Inhibitors, Tyrosine Kinase Inhibitors, and Mitotic Spindle Stabilizers

January 2011

New cancer drugs can cause skin side effects like rashes, dry skin, hair changes, and nail problems.

research Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells

9 citations, March 2018 in “International journal of molecular sciences”

Allopregnanolone changes gene expression in glioblastoma cells.

research The Control of Hair Growth: An Overview

62 citations, July 1993 in “Journal of Investigative Dermatology”

Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.

research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

82 citations, May 2009 in “Development”

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

research Perspectives in Dermatopathology: Telomeres and Telomerase in Aging and Cancer with Emphasis on Cutaneous Disease

11 citations, January 2000 in “Journal of Cutaneous Pathology”

Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.

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community Wtf have we been doing for the last 30 years

in Treatment 521 upvotes 3 days ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Medications that cause extra hair growth

in Research/Science 123 upvotes 1 year ago

The post discusses the side effects of various drugs causing excess hair growth, questioning why only minoxidil is used in the hair loss industry. The conversation includes users sharing their experiences and concerns about potential side effects of these drugs, with some preferring baldness over potential health risks.

community Dutasteride broked my liver (maybe)

in Finasteride/Dutasteride 8 upvotes 2 years ago

A user shared their experience with high cholesterol, glucose, and potential metabolic syndrome after using Finasteride and Dutasteride for hair loss. They plan to improve their health with diet and exercise before considering medication.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

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