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      research Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation

      December 2025 in “npj Systems Biology and Applications”
      This study found that cold exposure disrupts the circadian rhythm in cultured human cells by reducing oscillation amplitude, which is restored upon rewarming, while human hair follicle cells showed minimal amplitude sensitivity to temperature changes, suggesting an evolutionary advantage related to Hopf bifurcation dynamics.

      research Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

      5 citations , February 2025 in “Cell Reports”
      In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.

      research Genetic Variants and Protective Immunity against SARS-CoV-2

      5 citations , December 2022 in “Genes”
      This review discusses the host genetic factors influencing COVID-19 susceptibility and pathogenesis, highlighting genetic variations that affect viral entry and immune responses, but reports no new experimental results.

      research Long-acting microneedle formulations

      1 citations , August 2023 in “Advanced Drug Delivery Reviews”
      This review discusses various microneedle technologies for long-acting drug delivery, highlighting design considerations and challenges in bringing these minimally invasive devices to market, but it reports no new clinical results.