July 2026 in “Cell Transplantation” This study systematically reviewed 43 articles on the role of fibroblasts, especially dermal papilla cells, in androgenic alopecia, identifying androgen signaling and related pathways as key drivers of hair follicle miniaturization, which supports targeting dermal papilla cell dysfunction as a therapeutic strategy.
August 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that ECMs produced by papillary fibroblasts showed the largest fibers and supported keratinocyte differentiation better than reticular fibroblast matrices, informing biomimetic material design for skin tissue engineering.
18 citations
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July 2012 in “Cell Biology International Reports” This study suggests that human mesenchymal stem cells have the potential to differentiate into dermal papilla cells both in vitro and in vivo.
4 citations
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June 2022 in “Journal of Cosmetic Dermatology” This study suggests that dermal fibroblast-conditioned medium containing multi-peptide factors may stimulate hair growth by enhancing growth factor expression and β-catenin regulation in hair follicle cells.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified distinct and diverse fibroblast populations in female scalp cells that lose their signature and identity with age, highlighting significant age-related changes, such as increased fibrosis, DNA damage, and senescence, which may affect scalp dermal support for healthy hair follicles.