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Glossary Discoid Lupus Erythematosus

chronic autoimmune condition causing red, scaly skin patches

Discoid Lupus Erythematosus (DLE) is a chronic autoimmune condition that primarily affects the skin, leading to the development of red, inflamed, and scaly patches, often on the face, scalp, and ears. These lesions can cause scarring and permanent hair loss if they occur on the scalp.

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research Discoid lupus erythematosus skin lesion distribution and characteristics in Black patients: a retrospective cohort study

19 citations , November 2021 in “Lupus Science & Medicine”

This study found that Black patients with discoid lupus erythematosus had significantly worse CLASI damage scores and higher odds for dyspigmentation, scalp involvement, and scarring alopecia compared to non-Black patients.

research S-1 induced discoid lupus erythematosus-like lesions and long-term complete response for para-aortic lymph node recurrence of pancreatic ductal adenocarcinoma: a case report

June 2018 in “Surgical Case Reports”

S-1 treatment led to a complete response in pancreatic cancer with manageable side effects.

research Cutaneous Lesions in Systemic Lupus Erythematosus

32 citations , September 1989 in “Medical Clinics of North America”

This review describes the types of skin lesions associated with systemic lupus erythematosus, discussing their histopathological features, serologic associations, pathogenesis, and prognostic implications.

research Successful Hair Re-growth with Multimodal Treatment of Early Cicatricial Alopecia in Discoid Lupus Erythematosus

11 citations , January 2009 in “Acta Dermato Venereologica”

In this case report, a 37-year-old man with discoid lupus erythematosus experienced around 80% hair regrowth after treatment with a combination of oral and topical therapies.

research Plucked hair follicles from patients with chronic discoid lupus erythematosus show a disease-specific molecular signature

17 citations , July 2019 in “Lupus Science & Medicine”

In this study, gene expression analysis of plucked hair follicles from scalp lesions was sufficient to differentiate chronic discoid lupus erythematosus from psoriasis and healthy controls, suggesting a non-invasive diagnostic potential.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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