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research Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis

122 citations , November 2014 in “BMC Medicine”

This research observed that oral testosterone replacement therapy significantly increases cardiovascular risk, while effects of injected or transdermal therapy on cardiovascular risk were not significant, prompting further investigation into these methods.

research The serum evaluation of sex hormones including DHEAs, DHT, testosterone in oral lichen planus patients

1 citations , May 2025 in “Scientific Reports”

In this study, researchers found no significant differences in serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology linked to the condition.

research The Effect of Finasteride on the Secretion of Testosterone, DHT, LH, FSH and Tissue Factors in the Testis of NMRI Mice:

June 2021 in “Archives of Advances in Biosciences”

This study suggests that finasteride at doses of 5 mg/kg BW or higher may adversely affect spermatogenesis and male fertility in NMRI mice.

research The expression of inducible nitric oxide synthase (iNOS) in the testis and epididymis of rats with a dihydrotestosterone (DHT) deficiency

28 citations , January 2009 in “Cellular & Molecular Biology Letters”

This study concluded that finasteride-induced DHT deficiency intensified constitutive iNOS expression in rat testicular and epididymal cells, suggesting a complex regulatory relationship needing further investigation.

research Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1

27 citations , February 2005 in “Journal of Cellular Biochemistry”

This study found that rat male costochondral chondrocytes, unlike female chondrocytes, respond to testosterone through metabolism to dihydrotestosterone, which shows a maturation-state dependent effect in male growth plate cells.

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Community Join

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community Low testosterone and dht. What should I do?

in Finasteride/Dutasteride 7 upvotes 2 years ago

The user has low testosterone and DHT levels and is considering taking finasteride for Norwood 2 hair loss with diffuse thinning. They are seeking advice on whether low DHT indicates high sensitivity to DHT in the scalp and opinions on their lab values.

community My DHT levels on 1400mg testosterone per week and 0.5mg dutasteride daily

346 upvotes 2 months ago

A bodybuilder uses 1400mg testosterone weekly, 400mg equipoise, and GH, with 0.5mg dutasteride daily to stabilize hair loss and manage DHT levels. The user reports no side effects from dutasteride and finds it effective, while also discussing costs and effectiveness of other treatments like RU58841 and minoxidil.

community How does testosterone and dht work?

14 upvotes 4 weeks ago

Hair loss is influenced by follicle sensitivity to DHT, which increases with age, rather than just testosterone levels. Treatments like finasteride and hair transplants are used to manage hair loss, with transplants needing medication to protect surrounding sensitive hair.

community My topical finasteride DHT test results (before and after)

in Finasteride/Dutasteride 27 upvotes 4 years ago

A user shared their experience using topical finasteride for 6 months, showing a reduction in DHT levels but no visible improvement in hair loss. They are considering switching to oral finasteride for potentially better results.

community Can testosterone alone cause hair loss even after nuking DHT?

in Research/Science 26 upvotes 7 months ago

Testosterone can still cause hair loss even when DHT is blocked by dutasteride, especially if hair follicles are sensitive. Topical treatments like RU58841 or pyrilutamide may help, but their long-term effectiveness is uncertain compared to dutasteride.

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Learn

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learn PP405

Can applying a mask with PP405 directly to thinning areas give your scalp the push it needs? No PP405 mask exists to test: PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, it is not an anti-DHT ingredient, and it is not on sale. Its registered Phase 2 trial (NCT06393452) measured safety, not regrowth, and a rinse-out mask is in any case the wrong format for reaching the follicle.

learn Ecklonia Cava

How does Ecklonia Cava help slow down hair loss in people with androgenetic alopecia? Ecklonia cava may slow hair loss by inhibiting the enzyme that converts testosterone to DHT.

learn horsetail extract

Is horsetail extract strong enough to help with androgenic alopecia, or only mild hair loss? No published human trial has tested horsetail extract as a treatment for androgenic alopecia; the available evidence is laboratory work and trials of silicon supplements, which point at hair quality rather than at DHT-driven pattern baldness.

learn Alfatradiol

Alfatradiol: Is it safe to use if I’m already on finasteride or minoxidil? No published study has tested alfatradiol together with finasteride or minoxidil, so there is no direct evidence either way — no reported interaction, but also nothing that looked for one. Community members commonly combine them without reporting problems; ask a prescriber before adding a second agent aimed at the same DHT pathway.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Omega 3

Is the omega-3 to omega-6 ratio in your diet feeding your hair problem without you knowing? Nutrition sources describe a lopsided omega-6 to omega-3 intake as pro-inflammatory, but no published human study shows that the dietary ratio changes 5-alpha reductase, scalp DHT or hair loss; the one relevant trial tested a commercial omega-3/6 plus antioxidant supplement in 120 women, not a change in dietary fat ratio.

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Overview

learn GT20029

research compound made to degrade androgen receptors in scalp

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Clinics

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Experts

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67
Hair Loss Specialist
Dr. Fernando Testi, MD
Benissa, Comunitat Valenciana, Spain

Dr. Fernando Testi, MD