Search

for
Search:

GlossaryDesmoglein 3

protein crucial for cell adhesion in skin and mucous membranes

Desmoglein 3 (Dsg3) is a protein that plays a crucial role in cell adhesion, specifically in the skin and mucous membranes. It is a component of desmosomes, which are structures that help cells stick together, providing strength and integrity to tissues. Defects or autoimmune attacks against Dsg3 can lead to conditions like pemphigus vulgaris, a disease characterized by blistering and erosion of the skin and mucous membranes.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 84 results

research Pseudo Pemphigus Phenotypes in Mice with Inactivated Desmoglein 3

5 citations, October 2015 in “The American journal of pathology”

Mice with a mutated Dsg3 gene showed severe symptoms but not the typical blistering of pemphigus vulgaris.

research Desmoglein 3-Mediated Mechanical Transadhesion Controls Epithelial Stem Cell Quiescence

October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Desmoglein 3 is important for keeping hair follicle stem cells inactive and maintaining their special properties.

Uncoupling Desmosomal Cadherin Adhesion Activates Quiescent Hair Follicle Stem Cells and Orchestrates Self-Organized Regeneration Through Outside-In Signaling

research Uncoupling Desmosomal Cadherin Adhesion Activates Quiescent Hair Follicle Stem Cells and Orchestrates Self-Organized Regeneration Through Outside-In Signaling

April 2023 in “Journal of Investigative Dermatology”

Disrupting a specific protein's function in hair follicle stem cells triggers their activation and a self-healing process.

research Imaging Nanoscale Changes in Desmosome Protein Organization

April 2018 in “Journal of Investigative Dermatology”

Desmoglein 3 organization in cell connections changes without calcium, affecting cell adhesion.

research A Novel Animal Model of Desmoglein 1 (Dsg1) Deficiency Reveals an Essential Role for Dsg1 in Epidermal Barrier Formation

April 2018 in “Journal of Investigative Dermatology”

Dsg1 is essential for maintaining a healthy skin barrier in mice.

View more "desmoglein-3" in research →

Community Join

0 / 0 results

— no results