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GlossaryDesmoglein 3

protein crucial for cell adhesion in skin and mucous membranes

Desmoglein 3 (Dsg3) is a protein that plays a crucial role in cell adhesion, specifically in the skin and mucous membranes. It is a component of desmosomes, which are structures that help cells stick together, providing strength and integrity to tissues. Defects or autoimmune attacks against Dsg3 can lead to conditions like pemphigus vulgaris, a disease characterized by blistering and erosion of the skin and mucous membranes.

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A Spontaneous Deletion Within the Desmoglein 3 Extracellular Domain of Mice Results in Hypomorphic Protein Expression, Immunodeficiency, and a Wasting Disease Phenotype

research A Spontaneous Deletion Within the Desmoglein 3 Extracellular Domain of Mice Results in Hypomorphic Protein Expression, Immunodeficiency, and a Wasting Disease Phenotype

11 citations, December 2014 in “The American journal of pathology”

A gene deletion in mice causes weak protein, immune issues, hair loss, airway problems, and wasting disease.

research Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding Locus

38 citations, September 1997 in “The journal of investigative dermatology/Journal of investigative dermatology”

A mutation in mice causes hair loss and skin issues due to a defect in a gene affecting cell adhesion.

Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

research Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

108 citations, July 2002 in “Molecular and cellular biology”

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

research The Lanceolate Hair Rat Phenotype Results from a Missense Mutation in a Calcium Coordinating Site of the Desmoglein 4 Gene

50 citations, February 2004 in “Genomics”

A gene mutation causes lanceolate hair in rats by disrupting hair shaft integrity.

research Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats

13 citations, August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Mutations in the DSG4 gene cause fragile, sparse hair in humans, mice, and rats.

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