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    GlossaryDermal Papilla-Like Cells

    lab-grown cells mimicking natural dermal papilla cells for hair growth

    Dermal Papilla-Like Cells (DPLCs) are lab-grown cells that mimic the properties and functions of natural dermal papilla cells, which are found at the base of hair follicles and play a crucial role in hair growth and regeneration. These cells are often used in research and therapeutic applications to study hair loss conditions like alopecia and to develop potential treatments for promoting hair regrowth.

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      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

      learn Exosomes

      Microscopic delivery system that sends growth-promoting signals to hair follicles

      learn KY19382

      compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

      learn Minoxidil

      An essential vasodilator with some anti-androgenic effects, has excellent safety record

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      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.