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    Did you mean Dedifferentiation?
    Glossary Dedifferentiation

    process where mature cells revert to a primitive state

    Dedifferentiation is a biological process where specialized, mature cells revert to a more primitive, unspecialized state. This can occur in response to injury or stress and is significant in regenerative medicine and cancer research, as it can lead to tissue repair or, conversely, uncontrolled cell growth.

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    Research 10 of 1000+

    1. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    2. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    3. Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice Journal of Clinical Investigation · 2019 · 136 citations
    4. Human melanocyte development and melanoma dedifferentiation at single cell resolution bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 9 citations
    5. The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008 · 127 citations
    6. Regulation of adipocyte dedifferentiation at the skin wound edge bioRxiv (Cold Spring Harbor Laboratory) · 2023
    7. In-vivo dedifferentiation of keratinocytes to epidermal stem cells The Lancet · 2002 · 1 citations
    8. Mécanismes moléculaires et cellulaires des processus de différenciation et de plasticité cellulaire pour la formation des adipocytes Thèses en ligne de l'Université Toulouse III (Université Toulouse III) · 2019
    9. 881 Ionizing radiation triggers dedifferentiation of outer root sheath cells into stem cell-like progenitors for hair follicle regeneration Journal of Investigative Dermatology · 2017
    10. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
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