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    Glossary Dedifferentiation

    process where mature cells revert to a primitive state

    Dedifferentiation is a biological process where specialized, mature cells revert to a more primitive, unspecialized state. This can occur in response to injury or stress and is significant in regenerative medicine and cancer research, as it can lead to tissue repair or, conversely, uncontrolled cell growth.

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    Research 30 of 1000+

    1. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    2. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    3. Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice Journal of Clinical Investigation · 2019 · 136 citations
    4. Human melanocyte development and melanoma dedifferentiation at single cell resolution bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 9 citations
    5. The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008 · 127 citations
    6. Regulation of adipocyte dedifferentiation at the skin wound edge bioRxiv (Cold Spring Harbor Laboratory) · 2023
    7. In-vivo dedifferentiation of keratinocytes to epidermal stem cells The Lancet · 2002 · 1 citations
    8. Mécanismes moléculaires et cellulaires des processus de différenciation et de plasticité cellulaire pour la formation des adipocytes Thèses en ligne de l'Université Toulouse III (Université Toulouse III) · 2019
    9. 881 Ionizing radiation triggers dedifferentiation of outer root sheath cells into stem cell-like progenitors for hair follicle regeneration Journal of Investigative Dermatology · 2017
    10. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
    11. Estudo comparativo entre exames clínico, dermatoscópico e anatomopatológico em portadores de alopecia frontal fibrosante, diferenciando melasma e líquen plano pigmentoso / A comparative study between clinical, dermatoscopic and pathological examinations in patients with frontal fibrosing alopecia, differentiating melasma from lichen planus pigmentosus Brazilian Journal of Health Review · 2022
    12. The Utility of De-epithelialization in Subcutaneous Skin Flap Transposition. PubMed · 2025
    13. Extraskeletal actions of vitamin D Annals of the New York Academy of Sciences · 2016 · 119 citations
    14. Associação do Microagulhamento e Fatores de Crescimento para Estímulo do Crescimento das Sobrancelhas Revista Saúde em Foco · 2022
    15. Localization of Cathepsins B, D, L, LAMP-1 and .MU.-Calpain in Developing Hair Follicles. ACTA HISTOCHEMICA ET CYTOCHEMICA · 2001 · 10 citations
    16. A UTILIZAÇÃO DE PLASMA RICO EM PLAQUETAS COMO POTENCIALIZADOR DO REJUVENESCIMENTO FACIAL EM PROCEDIMENTOS ESTÉTICOS Revista Foco · 2024 · 1 citations
    17. Hétérogénéité tumorale du cancer de la prostate et infection par le SARS-CoV2 : une relation complexe impliquant les vésicules extracellulaires et le récepteur des androgènes SPIRE - Sciences Po Institutional REpository · 2023
    18. El sistema español de autonomías territoriales: apuntes para un diagnóstico Journal of the American Academy of Dermatology · 2009
    19. Avaliação do perfil fenotípico, proliferativo e secretório de células-tronco mesenquimais do tecido adiposo captadas por lipoaspiração assistida por laser 2023
    20. Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation Frontiers in Cell and Developmental Biology · 2020 · 18 citations
    21. Tailored chromatin modulation to promote tissue regeneration Seminars in Cell & Developmental Biology · 2019 · 10 citations
    22. Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model · 2017 · 3 citations
    23. Epidermis reconstructed from the outer root sheath of human hair follicle. Effect of retinoic acid Archives of Dermatological Research · 1993 · 18 citations
    24. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    25. Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals Proceedings of the National Academy of Sciences · 2005 · 130 citations
    26. Switching roles: the functional plasticity of adult tissue stem cells The EMBO Journal · 2015 · 87 citations
    27. The regeneration blastema of lizards: an amniote model for the study of appendage replacement Regeneration · 2015 · 39 citations
    28. Clonal analysis of stem cells in differentiation and disease Current Opinion in Cell Biology · 2016 · 11 citations
    29. Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair Nature Communications · 2026
    30. Cellular Plasticity in Cutaneous Wound Healing Biomedical Journal of Scientific & Technical Research · 2018