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    Did you mean Dedifferentiation?
    GlossaryDedifferentiation

    process where mature cells revert to a primitive state

    Dedifferentiation is a biological process where specialized, mature cells revert to a more primitive, unspecialized state. This can occur in response to injury or stress and is significant in regenerative medicine and cancer research, as it can lead to tissue repair or, conversely, uncontrolled cell growth.

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      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Does melatonin dissolve in isopropyl alcohol

      in Technology  8 upvotes 1 year ago
      The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  862 upvotes 3 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Verteporfin and Microneedling

      in Treatments 8 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Minoxidil is connecting the hair on the inner part of my arms

      in Satire 1 year ago
      This conversation is about a user who has been using Minoxidil for nine months and just noticed hair growing on the inner part of their arms. Responses to this post suggest that they should continue using it, with an increase in frequency from 5% twice a day, as well as trying finasteride if needed.

      community The first three months on minoxidil 2%

      in Is this regrowth?  1 upvotes 4 months ago
      The user noticed hair thinning and has been using a treatment with minoxidil 2%, hydrocortisone butyrate, and 17 alpha estradiol for three months, seeing some regrowth. The user had dermatitis, now cured, which worsened the hair loss.

      community My fin experience over 13+ years

      in Chat  150 upvotes 2 years ago
      The user's experience and success with taking finasteride to treat hair loss, which is confirmed by other users who have taken it without side effects. The user also advises that consulting a doctor before starting any kind of treatment for hair loss is important, as opposed to relying on self-made remedies available online.

      community DHT Isn't (Directly) Important

      in Research/Science  100 upvotes 6 days ago
      Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

      community Mexican balding victim here, 3 months

      in Is this regrowth?  49 upvotes 2 weeks ago
      A user started using oral minoxidil (2.5 mg) and dutasteride (1 mg) for hair loss three months ago and noticed no side effects, possibly due to regular exercise. They speculate a possible link between COVID-19 and accelerated hair loss.

      community Help finding a shampoo in Spain

      in Ketoconazole  3 upvotes 6 months ago
      A user is seeking a Ketoconazole shampoo in Spain to complement their hair loss treatment, which includes Minoxidil, Finasteride, and Biotin. They previously used Alpecin and are now looking for recommendations on Amazon.

      community Anyone Use Stemoxydine? Legit Sources?

      in Product  4 upvotes 10 months ago
      Someone asked if Stemoxydine is effective for hair loss and if it improves hair growth or thickness. They also requested safe purchasing sources due to concerns about counterfeit products.

      community Survived First Monte. Shedding is real

      in Progress Pictures  370 upvotes 10 months ago
      The user is treating hair loss with 1mg finasteride every other day, daily topical minoxidil, and weekly derma rolling, and is considering using hair fibers for special occasions. There is a discussion about the initial shedding phase of minoxidil treatment and the importance of consistent photo conditions to track progress.

      community 4kg of fin + 3 L of minox a day + plus micro 6 times a day, results?

      in Satire  657 upvotes 1 year ago
      The post discusses hair loss treatments, specifically using large amounts of finasteride, minoxidil, and micro-needling. The comments suggest various other remedies, like monkey oil, rosemary oil, and biotin, while some advise to embrace baldness and focus on confidence.

      community 5% Minoxidil after 4 months - started with twice a day but went down to once because I kept forgetting in the morning. Really happy with how it is going!

      in Progress Pictures  438 upvotes 1 year ago
      The conclusion of the conversation is that the user started using 5% Minoxidil for hair loss and is happy with the progress. They also mentioned being trans and coming off testosterone, which they believe will help prevent further hair loss. Some users suggested using finasteride as well.

      community My 2 year and 6 months progress. Finasteride 1 mg

      in Progress Pictures  167 upvotes 3 years ago
      A 31-year-old man shared his 2.6-year hair loss treatment progress, using 1 mg of finasteride daily, micro-needling every other week, and biotin vitamins, with no side effects and varying amounts of shedding. Other users discussed their own experiences with hair loss treatments, including the use of oral minoxidil and the long-term effectiveness of finasteride.