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Research

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research The Effects of Multiple Power Densities of Carbon Dioxide Laser on Photothermal Damage in Rat Skin Tissue

May 2023 in “Current Applied Science and Technology”

In this animal study, researchers found that exposure to a CO2 laser at various power levels caused significant skin damage in rats, including severe burns, coagulation, and tissue obliteration, with higher laser doses resulting in more pronounced injuries.

research Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

14 citations , January 2014 in “Cells Tissues Organs”

This study found that single high-dose irradiation in mice induced more severe acute skin injury and hair depigmentation, while fractional doses led to longer-term damage in the dermis and subcutis.

research Author response: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

November 2021

This study found that the loss of papillary fibroblasts in the skin due to UV radiation is mainly caused by an uncontrolled inflammatory response, with T cells helping fibroblast survival.

research Optothermal response and Tissue Damage analysis during Laser Hair Removal

February 2020 in “Journal of Physics Conference Series”

This study found that laser hair removal is optimal for light to moderate skin tones using 10-15 J/cm² at 755 nm and for dark skin with 4.5-10 J/cm² at 755-1064 nm.

research Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage

30 citations , September 2014 in “Journal of Investigative Dermatology”

This study found that certain chemotherapeutic agents, such as cyclophosphamide, disrupt feather formation and induce hair loss in mice by inhibiting cell proliferation through sonic hedgehog gene downregulation.

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Community Join

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community Could microneedling for the next 5 years cause any permanent damage?

in Microneedling 22 upvotes 3 years ago

Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scar tissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.

community Injured temple with derma rolling

in Microneedling 2 upvotes 2 years ago

OP injured their temple using derma rolling and tretinoin, causing peeling and potential hair follicle damage. Users suggest the injury might be permanent, possibly resulting in scar tissue where hair won't grow.

community I need some guidance...

6 years ago

A user experienced hair thinning due to traction alopecia from using Murray's Beeswax and is considering treatments like minoxidil and finasteride to reverse the damage. Another user suggests consulting a hair specialist, as the hair may not regrow if scar tissue has formed.

community Does microneedling damage scalp?

in Research/Science 12 upvotes 2 years ago

Microneedling does not prevent future hair transplants, but some surgeons report the skin becomes "harder" in treated areas. There is no clear evidence to confirm this effect.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

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Learn

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learn L-cysteine

Can topical products with L-cysteine repair damaged hair or prevent breakage? No controlled studies show that topical L-cysteine products repair damaged hair or prevent breakage; hair outside the scalp is not living tissue and cannot regenerate.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Providers say SMP sits above the hair follicles and does not harm them. No study has tested this, and infection or scarring from any tattoo can affect the skin.

learn Ketoconazole

Ketoconazole: Is it safe to use every day or can it damage my hair? Ketoconazole shampoo labels describe intermittent use (the US 1% label says every 3–4 days), and no published trial has tested daily use for hair loss. The labels list dryness and irritation among reported side effects.

learn Sulforaphane

Can sulforaphane protect hair follicles from inflammation and damage? In lab and mouse studies, sulforaphane reduced markers of inflammation and oxidative stress. No human study has tested whether it protects hair follicles.

learn Vitis vinifera

Does Vitis vinifera help protect hair follicles from damage? Grape compounds show antioxidant activity in lab studies and affected the hair cycle in mice; no study, in animals or people, shows they protect hair follicles.

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