81 citations
,
February 1997 in “Journal of Investigative Dermatology”
This study suggests that minoxidil activates PGHS-1, which may explain its hair growth-stimulating effects and could aid in designing more potent hair growth-promoting drugs.
3 citations
,
November 2022 in “Molecules/Molecules online/Molecules annual”
This study found that ingesting Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. extract promoted hair regrowth and follicle maturation in mice by enhancing cytoprotectiveeffects and growth factor expression.
This study concluded that extracts from fermented pumpkin peel and pulp, processed with Lactobacillus strains and kombucha, may serve as multifunctional cosmetic ingredients, offering antioxidant protection, anti-aging, and skin regeneration benefits by demonstrating cytoprotectiveeffects and reducing inflammatory cytokines in cell assays.
Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.