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research Cyclic ADP-Ribose Modulates Intracellular Calcium Homeostasis and Anagen-Associated Signaling Pathways in Human Hair Follicle Dermal Papilla Cells

January 2026 in “Applied Sciences”

Cyclic ADP-ribose helps regulate calcium and signals that promote hair growth in hair follicle cells.

research A Pilot Study Evaluating the Efficacy of Topically Applied Niacin Derivatives for Treatment of Female Pattern Alopecia

27 citations , December 2005 in “Journal of Cosmetic Dermatology”

Niacin derivatives may increase hair fullness in women with hair loss.

research A Review of the Impact of Calorie Restriction on Stem Cell Potency

4 citations , August 2021 in “The Malaysian journal of medical sciences/The Malaysian Journal of Medical Science”

Eating fewer calories improves the ability of stem cells to repair and renew the body in various tissues.

research Metabolic Regulation of Stem Cells in Aging

1 citations , April 2021 in “Current Stem Cell Reports”

Eating less can improve stem cell function and increase lifespan.

research Regeneration, Wound Healing, and Cancer

1 citations , November 2017

The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.

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Community Join

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community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 1 week ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community 6.5 Month Progression 33/Female

in Female 49 upvotes 3 years ago

Maintaining scalp hair and minimizing shedding, treatments used such as Procapil, supplements, topical caffeine, topical estrogen, and scalp massage; suggestions for anagen extenders or pharmaceuticals to help with a short anagen phase.

community Fin and Oral Minoxidil completely changed my hair texture (8months progress)

in Progress Pictures 353 upvotes 1 year ago

Finasteride and oral minoxidil significantly improved hair texture and thickness over 8 months. The user also experienced increased hair growth on the beard and eyebrows.

community (M28) 3 months progress on minoxidil 5%

in Progress Pictures 76 upvotes 1 year ago

A 28-year-old male showed hair regrowth after 3 months using 5% liquid minoxidil twice daily and weekly dermarolling with a 1mm roller. Someone suggested adding finasteride to the treatment.

community Meta analysis: Topical or mesotherapy dutasteride is more effective than topical finasteride in the treatment of AGA in men

in Research/Science 17 upvotes 3 years ago

Topical Dutasteride is more effective than topical Finasteride for treating AGA in men, with fewer side effects. Mesotherapy with Dutasteride, administered every 3 months, shows promising results for hair regrowth and maintenance without daily routines or significant side effects.

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