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GlossaryMT-CO1 (COX1)

encodes a key enzyme subunit for cellular energy production

MT-CO1, also known as Mitochondrially Encoded Cytochrome C Oxidase I, is a gene found in mitochondrial DNA that encodes a key subunit of the enzyme cytochrome c oxidase. This enzyme is crucial for the electron transport chain, which is a series of reactions that produce energy in the form of ATP within cells. Mutations in MT-CO1 can affect cellular energy production and are associated with various mitochondrial disorders.

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research Type 2-Mediated Oxidative Reprogramming Promotes Macrophage Transition into Repair Mode for Wound Healing

April 2023 in “Journal of Investigative Dermatology”

Type 2 inflammation helps wound healing by switching immune cells to repair mode.

Major Depletion of SOX2+ Stem Cells in the Adult Pituitary Is Not Restored and Does Not Affect Hormonal Cell Homeostasis and Remodeling

research Major Depletion of SOX2+ Stem Cells in the Adult Pituitary Is Not Restored and Does Not Affect Hormonal Cell Homeostasis and Remodeling

22 citations, November 2017 in “Scientific Reports”

The pituitary gland functions normally even after losing most SOX2+ stem cells.

research Maternal Nutrition at Conception Modulates DNA Methylation of Human Metastable Epialleles

432 citations, April 2014 in “Nature communications”

A mother's diet at conception can cause lasting genetic changes in her child.

research The Browning of White Adipose Tissue: Some Burning Issues

437 citations, August 2014 in “Cell metabolism”

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

research Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

57 citations, February 2014 in “Experimental Dermatology”

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

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community Painkillers May Block Minoxidil

in Research/Science 16 upvotes 4 weeks ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

in Research/Science 3 upvotes 1 month ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

community Correct way to microneedling, with existent hair

in Microneedling 12 upvotes 11 months ago

The conversation discusses the correct method of microneedling for hair loss, questioning whether it should be done on areas with long hair without risking hair damage, and if it's necessary for improving blood flow to existing hair. No specific treatments were mentioned.