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Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

research Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

12 citations, March 1995 in “Journal of the American Chemical Society”

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

research Keratin Function and Regulation in Tissue Homeostasis and Pathogenesis

7 citations, April 2012 in “Biomolecular concepts”

Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.

research Novel Advances of Histone Modification in Inflammatory Skin Diseases and Related Treatment Methods

January 2024 in “Frontiers in immunology”

Histone modification is key in treating chronic inflammatory skin diseases.

Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

research Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

38 citations, October 2011 in “Analytical biochemistry”

Hair proteins have weak spots in their α-helical segments.

research Epigenetics of Colorectal Cancer

218 citations, September 2012 in “Gastroenterology”

Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.

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community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 35 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.