2 citations
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June 2022 in “Cells” The study found that growing dermal papilla cells in 3D spheroids enhances their activity with hair growth-promoting agents, such as minoxidil and TCQA, compared to traditional 2D cultures.
10 citations
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August 1998 in “Journal of Investigative Dermatology” This study observed that the compound EM-402 reduced 5α-reductase activity and sebaceous gland size in the flank organs and ears of hamsters, indicating potent localized anti-androgenic effects without systemic action.
December 2022 in “Scientific Reports” This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.
This literature review on neurocosmetics found that both nature-derived peptides and synthetic molecules can improve skin concerns like aging and pigmentation, while also promoting emotional well-being; however, gaps in long-term efficacy and personalized approaches remain.
20 citations
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February 2002 in “Expert Opinion on Therapeutic Patents” This review discusses the potential uses of 5α-reductase inhibitors for conditions ranging from benign prostatic hyperplasia to skin disorders like acne and male pattern baldness, but it reports no new clinical results.