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Glossary ZIP4

zinc transporter protein crucial for cellular zinc uptake

ZIP4 is a zinc transporter protein that plays a crucial role in the uptake of zinc into cells. Zinc is an essential mineral for various biological functions, including immune response, DNA synthesis, and cell division. In the context of hair and alopecia, proper zinc levels are important for maintaining healthy hair growth, and disruptions in zinc transport can potentially contribute to hair loss conditions.

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community Did some new info come out about PP405? Everyone seems so pessimistic about it recently and I don’t know why.

1 upvotes 1 month ago

People are pessimistic about PP405, believed to be Jxl-069, due to doubts about its effectiveness and delivery method. Some think it doesn't work, while others blame the vehicle used for application.

community Why you can still look forward to PP405 and JXL-069

22 upvotes 1 month ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

community Pp405 any site for buying in Europe

4 months ago

PP405 is not commercially available or legitimate in Europe. Users are discussing the lack of availability of this product.

community reminder: Pyrilutamide 0.9% (kx-826) ships to Europe from Amazon US and Koshinemall

9 upvotes 1 year ago

Pyrilutamide 0.9% (kx-826) is available for shipping to Europe from Amazon US and Koshinemall. Shipping costs and availability vary between the two shops.

community Happy 4th of July! Verteporfin update.

in Product 64 upvotes 2 years ago

The conversation discusses hair loss treatments, specifically Verteporfin. Users also mention Minoxidil, finasteride, and RU58841.

community PP405 (JXL069) Is Confirmed: Here’s Everything I’ve Learned After a Year of Testing

80 upvotes 1 month ago

JXL069, also known as PP405, did not lead to hair regrowth after a year of testing. The lack of results may be due to formulation issues, leading to a final attempt with an improved vehicle.

community The final nail in the coffin. PP405 is confirmed JXL069.

440 upvotes 1 month ago

PP405 and JXL069 are confirmed to be the same molecule, leading to disappointment due to poor hair regrowth results. Users express skepticism about the credibility of Pelage and the effectiveness of JXL069.

community 4 month is in - 2 pics - fin/min+

in Progress Pictures 386 upvotes 1 year ago

The user shared a 4-month update on their hair regrowth journey using finasteride, minoxidil, and microneedling, reporting significant progress and styling ability. They emphasized persistence, shared their regimen details, and addressed side effects like weaker erections and blurry vision, which improved with lifestyle changes.

community Having Ru58841 mailed to my house

in Research/Science 1 upvotes 7 months ago

RU58841 can be ordered as a powder and compounded at home, but it should be stored at room temperature to avoid crystallization. Pyraulatmide may follow a similar principle.

community PG free Ru58841 solvent in the UK

2 upvotes 3 weeks ago

The conversation discusses finding a PG-free solvent for dissolving RU58841 in the UK, with glycerin suggested as a potential alternative. Water is also mentioned as a possible option.

community PP405 is NOT gray market jxl069

in Technology 26 upvotes 7 months ago

PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

community SCUBE 3 (the last hair bender)

2 upvotes 1 year ago

SCUBE3 and Amplifica's progress in hair loss treatment is being discussed, with inquiries about their current status and clinical trials. No specific updates or new information are provided in the conversation.

community Does anyone know the chemical formula for pelage pp405?

15 upvotes 1 year ago

The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

community Verteporfin Update #4: Month 5 | Dr Blake Bloxham, Feller & Bloxham Medical

13 upvotes 2 years ago

The conversation discusses patient updates on hair loss treatment with Verteporfin after five months, as reported by Dr. Blake Bloxham. Patients voluntarily sent their progress pictures to Dr. Bloxham.

community PP405 gets its generic name - Suvomipic

287 upvotes 1 month ago

Suvomipic, previously known as PP405, is progressing to Phase 3 trials for hair loss treatment. Its effectiveness compared to existing treatments like Minoxidil and Finasteride is still uncertain.

community Kintors interim report from 9-2-24 for everyone whos interested

32 upvotes 2 years ago

Kintor plans to release pyrilutamide foam and a plant-based Koshine by year-end, with GT20029 progressing in their pipeline. Users are pleased about the absence of propylene glycol (PG) in the new products.

community Verteporfin update - Dr Barghouthi finishes another case

in Research/Science 17 upvotes 2 years ago

A hair restoration case involved injecting four different doses of Verteporfin into the mid scalp and using Scalp MicroPigmentation (SMP) around the extraction areas. Photos were taken and an update will be shared soon.

community Jxl069 (pp405 api) week 8 update

205 upvotes 1 year ago

The user shared minimal results from using JXL-069 for hair loss, noting a slight lengthening of vellus hairs and plans to switch to a prodrug variant due to limited effectiveness. They also mentioned using finasteride and minoxidil, which have plateaued in results.

community EveryChem 3HP / PP30 page data vs NMR PDFs in their website : metadata mistake or document mismatch?

in Research/Science 15 upvotes 5 months ago

There is an inconsistency between the molecular weight and formula listed on EveryChem's product page and the analytical PDFs for 3HP and PP30, suggesting a possible error in the product description. Concerns are raised about EveryChem's business practices and lack of transparency in testing and manufacturing.

community PP405 (Everychem 3HP) Users - Assemble and share your story!

in Chat 19 upvotes 4 months ago

Users discussed the effectiveness of Everychem's solution, similar to PP405, with some reporting improved hair thickness and new growth. Concerns were raised about safety and the legitimacy of the product, with some users advising against purchasing research chemicals.

community 4 month Min+Fin progress (topical)

in Progress Pictures 124 upvotes 2 years ago

A user shared their 4-month progress using a topical solution with 5% minoxidil and 0.1% finasteride, applied twice daily. They reported good results despite occasional missed applications.

community Black market pp405? Title title

in Treatment 8 upvotes 8 months ago

PP405 is likely fake, and JXL069 is an unrefined prototype with unknown side effects. It's advised to wait for the official PP405 release.

community mallia therapeutics 8T3 scd83 molecule for ffa/lpp mainly and aga

in Technology 9 upvotes 7 months ago

A user applied the 8T3 product for hair loss, targeting LPP and AGA, and plans to update on its effectiveness. The product uses a saline buffered phosphate vehicle, suitable for those intolerant to ethanolic vehicles.

community 4 months 0.25 mg finasteride only

in Progress Pictures 167 upvotes 2 years ago

A user shared their 4-month progress using 0.25 mg finasteride daily for hair loss, reporting significant improvement and minimal side effects. Other users discussed their experiences with different dosages and side effects.

community Anyone heard of scube3? And other emerging treatments?

in Research/Science 4 upvotes 1 year ago

Emerging hair loss treatments like PP405, a topical MPC inhibitor, show promise in activating stem cells for hair growth. The conversation seeks information on the development stages and accessibility of these treatments.

community Why doesn't phase 3 of PP405 start straight away?

in Chat 14 upvotes 8 months ago

Pelage is delaying the start of phase 3 trials for PP405 to 2026 due to necessary regulatory processes, despite having $120 million in funding. Users discuss the potential of PP405 for hair regrowth, with some expressing skepticism and others hopeful for new treatments like Breezula.

community JXL082 is not PP405 and Everychem followed the wrong lead

41 upvotes 1 year ago

JXL082 is not the same as PP405, leading to a halt in sales and a plan to synthesize the real PP405. There is skepticism about the safety and effectiveness of JXL082 and PP405, with concerns about patent issues and the long-term impact on hair growth.

community Amplifica and AMP-303 clinical phase 1

9 upvotes 2 years ago

Amplifica is testing a compound called AMP-303 for hair loss, but it's not Scube3 or osteopontin. The timing for the results from the clinical trial is unknown.

community What is the chance that the pp405 molecule gets leaked to the grey market in phase 3?

18 upvotes 11 months ago

The conversation discusses the potential availability and use of the pp405 molecule for hair loss treatment, with concerns about its legitimacy and safety on the grey market. Participants also mention using products from Umbrella Labs and discuss the concentration and production costs of pp405.

community Breezula sold at Anagen Inc & Universal Labs - has anyone tried it?

9 upvotes 8 months ago

Breezula is being sold at Anagen Inc and Universal Labs, and users are discussing their experiences and results with it. There is also interest in the formulation process and inquiries about PP405.