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Did you mean Reverse Phase High Performance Liquid Chromatography?

Glossary Reverse Phase High Performance Liquid Chromatography

technique separating mixture components using non-polar stationary phase

Reverse Phase High Performance Liquid Chromatography (RP-HPLC) is a technique used to separate, identify, and quantify components in a mixture. It involves a non-polar stationary phase and a polar mobile phase, meaning that non-polar compounds in the mixture will interact more with the stationary phase and thus move more slowly through the system, allowing for effective separation based on polarity.

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community Husband (35) is thinning on top, he doesn't know yet. Trying to research so he won't feel so lost or upset when I tell him. Help a girl out?

in Research/Science 160 upvotes 1 year ago

A woman is concerned about her husband's hair thinning and researches treatments like finasteride and minoxidil. He decides against medication due to potential side effects and plans to shave his head if necessary.

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

186 upvotes 1 year ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community What the Breezula Phase III results mean & realistic timeline

59 upvotes 9 months ago

Breezula offers modest hair growth similar to finasteride and is expected to be available by late 2026. It is a safe alternative without hormonal side effects and works well with minoxidil.

community Exploring Bryan Johnson's Hair Routine In Detail

64 upvotes 2 years ago

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

community 0.5mg Dutasteride promotes more “regrowth” than 5mg oral Minoxidil

in Research/Science 117 upvotes 2 years ago

Dutasteride promotes more hair regrowth than Minoxidil. Users discuss combining treatments for better results and share personal experiences with side effects.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 1 year ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

community How Dangerous is Oral Min Really?

in Minoxidil 26 upvotes 1 year ago

Oral minoxidil is generally effective for hair loss but may cause side effects like heart palpitations and facial puffiness. Users highlight the importance of monitoring blood pressure due to potential cardiovascular risks.

community Why don't we all just take 2.5mg dutasteride?

in Finasteride/Dutasteride 45 upvotes 11 months ago

Switching from finasteride and minoxidil to a higher dose of dutasteride for hair loss is debated due to potential side effects. Many suggest starting with lower doses or sticking to finasteride if effective.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

308 upvotes 1 year ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.

community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community M25: Getting way too many DMs, so let’s do this here! AMA about Male Pattern Baldness, Hair Loss, and Products (100% Science-Backed )

1951 upvotes 5 months ago

Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.

community Creatine and hair loss (personal experience)

95 upvotes 1 year ago

Creatine can cause increased hair loss in some people, particularly those with a predisposition to androgenic alopecia, but hair loss often stops after discontinuing its use. Some users experience no hair loss while using creatine.

community Creatine in People Who Take DHT

87 upvotes 1 year ago

Finasteride users have mixed experiences with creatine; some experience increased hair loss, while others do not. Finasteride's DHT-blocking effects might counteract any DHT increase from creatine, but individual responses vary.

community Does whey protein and creatine aggravate hair loss?

79 upvotes 2 years ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community Accelerated Hair Loss from Creatine

137 upvotes 10 months ago

Creatine may cause hair loss in some individuals, especially those on finasteride, despite no scientific link. Personal experiences suggest individual sensitivity to DHT could be a factor.

community I have tried many treatments but it's getting worse. 23M.

90 upvotes 1 year ago

A 23-year-old male experiencing worsening hair loss has tried topical Minoxidil, Finasteride, Progesterone, Hydrocortisone butyrate, and Ketoconazole. He is considering switching to oral Finasteride due to concerns about side effects and lack of improvement.

community KX826 New Phase 3 Trial In China for 2025: 1.0% concentration

62 upvotes 1 year ago

KX-826 is undergoing Phase III trials in China as a potential treatment for male pattern baldness, with some users considering it as an alternative or addition to finasteride and dutasteride. Opinions on its effectiveness vary, with some users reporting positive results and others finding it expensive and ineffective.

community 22M High Estrogen after blood test

1 upvotes 7 months ago

A 22-year-old male with high estrogen levels is considering finasteride for hair loss but is concerned about potential side effects due to his hormone levels and family history of diabetes. Users suggest consulting a doctor, possibly an endocrinologist, and considering lifestyle changes like diet and exercise to address visceral fat and insulin resistance before starting treatment.

community Pelage are starting phase 3 for PP405 towards the end of 2026

in Chat 180 upvotes 7 months ago

PP405 is moving to late-stage trials, showing potential for hair regrowth, with 31% of male patients experiencing a 20% increase in hair density. Veradermics is developing an oral minoxidil version, and there is interest in combining treatments for better results.

community A New Hair Loss Drug Could Cure Balding and Reverse Graying

367 upvotes 10 months ago

ABS-201, a prolactin receptor blocker, shows promise in reversing hair loss and graying, with early success in macaques. Current treatments like finasteride, minoxidil, and RU58841 are still widely used, but new options like PP405 are eagerly anticipated.

community Scientists May Have Accidentally Found a Way to Reverse Hair Loss Without Drugs

877 upvotes 1 year ago

2-deoxy-D-ribose is being explored as a hair loss treatment but is not proven effective in humans and may be costly and inconvenient. Minoxidil remains the most effective treatment.

community Waiting to start treatment until Kintor KX-826 Phase 2 data is published?

17 upvotes 4 years ago

People are waiting for KX-826 (Pyrilutamide) Phase 2 data to decide on hair loss treatments, with some considering finasteride or minoxidil in the meantime. Pyrilutamide is seen as a potentially stronger and safer alternative to finasteride, but concerns about side effects and availability remain.

community Apart from Finasteride, Minoxidil, and Microneedling what are you doing to reverse balding?

216 upvotes 1 year ago

Various treatments for hair loss include minoxidil injections, finasteride, dutasteride, microneedling, Nizoral shampoo, and supplements like vitamin D and biotin. Additional methods mentioned are red light therapy, scalp massages, lifestyle changes, and hair transplants.

community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 1 year ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

276 upvotes 6 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

community When could we expect pp405 to hit the market?

31 upvotes 1 year ago

PP405 is expected to finish Phase 2 trials in late 2025, with potential market availability around 2028-2029 if all goes well. Current treatments like finasteride and minoxidil are still popular, while new options like KX-826 and Breezula are anticipated soon.

community Realistically, how much PP405 will cost?

33 upvotes 1 year ago

PP405 is in phase 2 trials for hair loss, with discussions on its cost and effectiveness compared to minoxidil and finasteride. Users are skeptical about its efficacy and timeline, with hopes for market release by 2027.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community The future of hair loss drugs.

34 upvotes 7 months ago

Clascoterone 5% and PP405 are being discussed as potential future treatments for hair loss, with clascoterone nearing phase three completion and PP405 possibly taking a cosmetic route to market. Current treatments like minoxidil, finasteride, and RU58841 are mentioned as effective in slowing hair loss, but a complete cure remains elusive.

community Question: can hair shedding happen multiple times when taking minoxidil and finasteride?

5 upvotes 1 year ago

A 30-year-old male experienced hair shedding while using Minoxidil and Finasteride, with concerns about whether this is a normal shedding phase. Despite drastic hair loss, he continues the treatment, hoping for regrowth, and receives advice to maintain the regimen and consider lifestyle changes.