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GlossaryPolygenic

trait influenced by multiple genes

Polygenic refers to a trait that is influenced by multiple genes rather than a single gene. For example, characteristics like height, skin color, and susceptibility to certain diseases, including some forms of alopecia, are polygenic, meaning they result from the combined effect of several genes, each contributing a small amount to the overall phenotype.

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community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 13 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?

in Finasteride/Dutasteride 95 upvotes 6 months ago

After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil.

community Try to find picture of Justin Bieber without a hat in the last two years - challenge impossible

in Chat 164 upvotes 7 months ago

The conversation discusses Justin Bieber's apparent hair loss and the public's reaction to it, with some speculating he's had a hair transplant or is avoiding hair loss medications due to side effects or medical conditions. There's also mention of his past comments on Prince William's balding and the irony of his current situation.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 22 upvotes 3 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community 3α-Hydroxysteroid dehydrogenase community driven study, not anytime soon guys.

in Research/Science 105 upvotes 3 years ago

High cost of studying 3α-Hydroxysteroid dehydrogenase in hair loss led to suggestions of crowdfunding for research. Users discussed using Procyanidin B2/melatonin topical treatment and tracking funds with blockchain.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 668 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.