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GlossaryPatched Receptor

protein controlling cell growth via Hedgehog signaling pathway

The Patched Receptor is a protein found on the surface of cells that plays a crucial role in regulating cell growth and development. It acts as a gatekeeper in the Hedgehog signaling pathway, which is important for embryonic development and tissue regeneration. When the Hedgehog protein binds to the Patched Receptor, it allows another protein called Smoothened to activate and send signals inside the cell, influencing gene expression. This pathway is also implicated in certain cancers when it malfunctions.

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community Anyone excited for CosmeRNA coming this month?

in Product 171 upvotes 1 year ago

CosmeRNA, a new hair loss treatment, is expected to release soon and may become part of the "big three" treatments alongside finasteride and minoxidil. It works differently from finasteride by targeting androgen receptors in hair follicles, potentially offering fewer side effects.

community 5 Month's progress on Topical FIN, MIN, Topical Dut, Laser Cap

in Progress Pictures 577 upvotes 3 years ago

User "hemantch" shares 5 months progress using topical Fin, Min, topical Dut, and a laser cap for hair loss. Significant regrowth was noticed after 1 month, and the treatments worked well despite being bald for 10 years.

community 10 months CB and Oral Minoxidil

in Progress Pictures 110 upvotes 8 months ago

A person with Alopecia Areata on their beard is using CB-03-01 and oral minoxidil for treatment. Some users question the effectiveness of CB-03-01 for beard hair, suggesting that minoxidil alone may be responsible for any observed hair growth.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

community Androgenic alopecia exclusively on the vertex of the scalp

in Chat 6 upvotes 7 months ago

A user experienced androgenic alopecia starting at the vertex without frontal hairline recession and is seeking information on this pattern. Another user noted that vertex or diffuse hair loss is common among men.

community I am having Success with RU58841 and 1mm Derma Roller

in Microneedling 19 upvotes 2 years ago

A user reported success with RU58841 and a 1mm derma roller for hair regrowth, noting significant improvement in hair density and reduced scalp visibility. They also mentioned using minoxidil and black castor oil in the past, with mixed results.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 3 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community Breaking hair loss news! GT20029 is a resounding success!

in Product 132 upvotes 8 months ago

GT20029, a new hair loss treatment, shows promising results but only a slight improvement over placebo. People are cautiously optimistic, discussing its potential and combining it with existing treatments like Minoxidil and Finasteride.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 8 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Starting Spironolactone, any ladies in here with experience or success?

in Female 56 upvotes 1 year ago

A female user starting Spironolactone treatment for thinning hair, and others sharing their experiences with Minoxidil and oral/sublingual Minoxidil as treatments.

community Been on Min and Fin for Years and I am Devastated.

in Treatment 64 upvotes 2 years ago

Guyman567 has been using oral finasteride and topical minoxidil for years but continues to experience hair loss and thinning, which has affected his confidence. He has tried various treatments including topical finasteride, microneedling, and vitamins, and is considering a hair transplant but is concerned about ongoing hair loss.

community 26, i was cool w shaving bald but I wanted to hold on for a little longer. Just topical min and rosemary shampoo.

in Progress Pictures 688 upvotes 1 year ago

The post and conversation are about a user's successful regrowth of hair using topical minoxidil and rosemary shampoo. Other users discuss the potential limitations of minoxidil and recommend using finasteride to maintain hair growth.

community Why only the top of the head?!

in Chat 2 years ago

Why the top of the head is affected by hair loss more than other areas, and treatments such as surgery, medications like minoxidil, finasteride, and RU58841 to treat it.

community I think we all hop on estrogen. It's the only angle

in Satire 83 upvotes 4 months ago

The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Diffuse thinning fucking sucks

in Update 430 upvotes 10 months ago

The conversation discusses various treatments for hair loss, including finasteride, minoxidil, dutasteride, microneedling, and checking for nutrient deficiencies. Some users suggest adding hydrocortisone butyrate, low-dose progesterone, or tretinoin to treatment regimens, while others recommend cosmetic solutions like Toppik hair fibers or shaving the head.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

in Chat 1 year ago

This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Start taking care of your skin and hair loss TODAY! I was telling myself I didn’t care, but I think the difference in my facial expression says it all. Take action asap before more permanent damage is done. I hope I can inspire some of you, because it’s so worth it. Not for others, for yourself! <3

in Progress Pictures 583 upvotes 2 years ago

User shared progress in treating hair loss and improving skin, using treatments like finasteride, minoxidil, RU58841, tretinoin, microneedling, and skin care regimen. Others commented on the impressive results and asked about costs and side effects.

community ~5 months topical minoxidil + oral finasteride results (swipe images). Slacked with minoxidil this past month, trying to wean off anyways. My last update because I’m hopping off fin and switching to RU in a few weeks (nothing to do with fin efficacy, just experimenting).

in Progress Pictures 145 upvotes 4 years ago

The user experienced significant hair thickening after using topical minoxidil and oral finasteride for about 5 months and is considering switching from finasteride to RU58841. Other users encourage the original poster to continue the current treatment due to the positive results.

community Is it me or are people losing their hair very young now?

in Finasteride/Dutasteride 143 upvotes 4 years ago

People notice more young individuals experiencing hair loss and discuss possible reasons, such as diet, hormones, and stress. Some treatments mentioned include finasteride, dutasteride, and minoxidil.

community Does Nuking Scalp DHT Theoretically Make Minoxidil Gains Permanent?

in Minoxidil 36 upvotes 1 month ago

Minoxidil gains are not permanent without continued use, even with DHT suppression. Combining treatments like Dutasteride, Finasteride, and RU58841 may help maintain hair, but stopping Minoxidil typically results in hair loss.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 8 months ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community 5 Months Hair Transplant Progress / 3500 Grafts

in Transplants 1663 upvotes 1 year ago

A user shared their positive experience with a hair transplant of 3500 grafts, showing significant improvement in appearance after 5 months. They underwent the procedure at Heva Clinic in Istanbul for $2,300 USD, which included aftercare, and attributed their hair loss to both genetics and traction alopecia from tight hairstyles.

community 1 year post Hair Transplant before and after. What level of shedding is normal

in Progress Pictures 1793 upvotes 1 year ago

The user, SnooDonuts9235, shares their positive experience with a hair transplant and using topical finasteride and minoxidil. They express concern about increased shedding and ask if it is normal. Other users compliment their results and ask about the clinic and procedure details. SnooDonuts9235 encourages others to consider a hair transplant even without taking oral finasteride and shares that the procedure was not as scary as they initially thought.

community 9 months fin 0.33mg daily - everything’s coming up millhouse

in Progress Pictures 81 upvotes 1 year ago

User started oral finasteride 0.33mg daily and later made a topical solution with cetirizine and stemoxydine. They experienced hair growth progress after 8-9 months and discussed factors affecting their results.

community 5 years of min / finasteride, no longer slowing loss.

in Finasteride/Dutasteride 37 upvotes 2 years ago

A user's experience of slowing hair loss while taking minoxidil and finasteride, and the various treatments suggested to help halt or reverse the process.

community I rather have receding temples than diffused thinning all over

in Chat 102 upvotes 3 years ago

User with diffused thinning hair prefers receding temples, as hair transplant could fix it. Finasteride and minoxidil suggested to improve hair density.