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GlossaryNeurosteroids

steroids produced in the brain that affect neuron function

Neurosteroids, also known as neuroactive steroids, are a class of steroids synthesized in the brain and nervous system. They play a crucial role in modulating neuronal activity, influencing mood, stress response, and cognitive functions by interacting with neurotransmitter receptors such as GABA and NMDA.

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community Why DUT mesotherapy is not considered the best hair loss treatment?

in Treatment 13 upvotes 2 years ago

Dutasteride Mesotherapy for hair loss is discussed, noting its potential to lower scalp DHT without side effects. Concerns include the inconvenience of injections, lack of reputable studies, and availability issues.

community I’ve been on oral finasteride/Proscar for 15 years. (AMA)

in Treatment 11 upvotes 5 months ago

A user has been on oral Finasteride/Proscar for 15 years and started using topical Minoxidil, RU58841, and Dutasteride, along with microneedling, 2 years ago. They shared progress pictures and discussed their treatment routine.

community I don’t even care about my hair I just like taking drugs

in Satire 1 year ago

A user's experimentation with various hair loss treatments, including medications and topical applications; as well as their desire to experience unusual sensations through the use of drugs.

community My Experience With Finasteride

in Research/Science 21 upvotes 1 year ago

A user shared their experience with Finasteride for hair loss, noting a significant reduction in DHT levels and a complete loss of libido without other side effects. Another user agreed, discussing the negative impact on sexual drive and criticizing the community's attitude towards discussing side effects.

community 1 Year on Finasteride - Here's what I think

in Finasteride 86 upvotes 5 years ago

A user shared their experience after one year on Finasteride, noting both positive effects on hair retention and minor side effects like reduced libido and high blood pressure. They also emphasized the importance of quitting porn to improve sexual health and mentioned using Viagra to boost confidence.

community I find it crazy how some people like this bloke have 0 DHT sensitivity. He is on grams of anabolic steroids and has a full, thick head of hair. I wish all of on here had this guys hair genes lol

in Satire 443 upvotes 1 year ago

The conversation is about hair loss and the possibility of maintaining a full head of hair while using anabolic steroids. Some users believe that having good hair genes and taking hair loss protocols can help prevent hair loss while on steroids.

community Nandrolone Replacement Therapy

in Treatment 41 upvotes 1 year ago

A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

community The no BS guide to saving your hair without finasteride (improvement in 90% of patients in the study) with a low side effect profile or improvement in 100% of patients but a higher side effect profile and increased dosage. The future is here?

in Minoxidil 92 upvotes 4 years ago

Hair loss treatments, specifically the use of oral minoxidil in combination with micro-needling. Oral minoxidil has been found to improve hair density in 90% of patients with a low side effect profile, but using 5mg per day can result in higher side effects including hypertrichosis and edema. Other treatments mentioned include finasteride and RU58841.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 2 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community I think I’m on to something

24 upvotes 5 years ago

The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.

community Just popped my first fin, excited as hell!

in Finasteride/Dutasteride 154 upvotes 6 months ago

A user shared their excitement about starting finasteride for hair loss after trying various ineffective methods. Other users discussed their experiences with finasteride, including shedding phases and side effects, with one mentioning using topical finasteride and minoxidil.

community Possible explanation of why Dutasteride seems to be worse for some people’s hair.

in Treatment 47 upvotes 1 year ago

The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

community HairCafe: The Broscience of Hair Loss, DHT, and Bludflow with Andrew Huberman

in Chat 1 year ago

Hair loss, DHT and bloodflow with Andrew Huberman; the discussion includes opinions about supplements, finasteride, minoxidil, turmeric, coffee and botox injections for hair loss.

community Completely defeated after trying so hard with topical finasteride.

in Finasteride/Dutasteride 24 upvotes 1 year ago

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

community Why I believe PFS is not a "real" condition (and what I believe it is instead)

in Finasteride/Dutasteride 14 upvotes 2 years ago

The post argues that Post-Finasteride Syndrome (PFS) is likely not real and suggests symptoms may be due to mental health issues or the nocebo effect. The conversation includes personal experiences with finasteride, highlighting both positive and negative effects, and emphasizes consulting doctors and using reliable sources for medication.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 5 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 5 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Insomnia and Finasteride

in Finasteride/Dutasteride 6 upvotes 3 years ago

A user reports experiencing insomnia as a side effect of taking finasteride for hair loss, which takes 1 to 2 hours to fall asleep and results in only about 5 hours of sleep per night. They suspect the cause is related to the downregulation of neurosteroids due to finasteride.

community Anyone here holding out for Breezula?

in Treatment 6 upvotes 4 years ago

The conversation is about individuals considering waiting for Breezula to treat hair loss instead of using Finasteride due to concerns about side effects. Some are opting for Finasteride now, while others are wary of its impact on neurosteroids.

community Progressive insomnia (treatment-resistant) due to Finasteride

in Finasteride/Dutasteride 7 upvotes 2 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

community My kid secretly took my avodart what should i do

in Is this regrowth? 42 upvotes 2 months ago

A child accidentally took Avodart, leading to concerns about DHT suppression and its effects. Users humorously discuss potential consequences and treatments like DHT injections and topical solutions.

community The Battle of Norwood (2024) | Dut 0.5 mg ED + Oral Min 5 mg ED

in Progress Pictures 513 upvotes 1 month ago

The conversation discusses hair regrowth using dutasteride and oral minoxidil, with the user reporting significant improvement in hair volume after combining these treatments. Some side effects mentioned include changes in libido and increased facial hair, but overall, the user is satisfied with the results.

community Finasteride and Its Effects on Cognition: Where's the Science?

in Research/Science 26 upvotes 4 years ago

The user shared their experience with hair loss treatments, including low-dose minoxidil, finasteride, and essential oils, and expressed concerns about the cognitive side effects of finasteride. They are seeking more information on how finasteride may affect cognition and are considering whether to continue or stop the treatment.

community The safest way to use finasteride - my research

in Finasteride 24 upvotes 7 years ago

The post discusses microdosing finasteride to minimize side effects while treating hair loss. The user also mentions using minoxidil, biotin, and ketoconazole.

community Oral or topical finasteride? .

in Chat 12 upvotes 4 months ago

A user is deciding between oral and topical finasteride for hair loss, noting oral finasteride's ease of use but broader effects. Another user simply recommends oral finasteride.

community The Bad Ending: You Lose Finasteride

in Satire 129 upvotes 4 months ago

The conversation humorously discusses the effects of stopping finasteride for two years, with users joking about hair loss and embracing baldness. Treatments mentioned include finasteride.

community ecklonia cava?

in Question 4 upvotes 5 years ago

The conversation discusses using ecklonia cava as a natural alternative to finasteride for hair loss. Users share their experiences and opinions on its effectiveness.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 5 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Tired of playing this game on hard mode? (not click bait).

in Treatment 7 months ago

Hair loss can be linked to low testosterone, affecting DHT and estrogen levels. Treatments discussed include increasing testosterone, using Finasteride, and applying estrogen cream.