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GlossaryKeratotic Plugs

small, hardened accumulations of keratin blocking hair follicles

Keratotic plugs, also known as keratin plugs or follicular plugs, are small, hardened accumulations of keratin and dead skin cells that block hair follicles. These plugs can lead to conditions like keratosis pilaris, where the skin becomes rough and bumpy, often resembling goosebumps. They are commonly found on the upper arms, thighs, and buttocks, and can sometimes cause inflammation or irritation.

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community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community What are these spots on my scalp

in Treatment 51 upvotes 5 months ago

A user noticed non-itchy, non-bleeding spots on their scalp while experiencing hair loss. Replies suggest the spots are likely sunspots or liver spots and recommend seeing a dermatologist; hair loss is attributed to male pattern baldness.

community When you're balding is it an absolute traumatic period of your life or do some people not care as much?

in Chat 89 upvotes 4 months ago

Balding can be traumatic for many, affecting self-esteem and social interactions, while others accept it more easily. Treatments mentioned include finasteride, minoxidil, and RU58841.

community Bryan Johnson just dropped his anti hair loss formula

in Treatment 339 upvotes 10 months ago

Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

community 22M Fin and min everyday for 10 months, looks like my right temple is still receding

in Finasteride/Dutasteride 67 upvotes 1 year ago

The user is seeking opinions on their hair loss, specifically the receding of their right temple. They are considering switching to Dutasteride but are unsure if it will help. Other users suggest that their hairline has improved with the use of Finasteride and Minoxidil. One user mentions using RU58841 to thicken their hairline.

community My skin is always dry and flakes like chalk (25)

in Transgender 6 upvotes 8 months ago

The user underwent a biopsy two years ago and was diagnosed with keratosis pilaris, leading to hair issues. They tried treatments including Minoxidil, betamethasone, lymecycline, topical Accutane, and dutasteride, as well as diet changes, without improvement in hair thickness or skin dryness.

community My Experience and a Discourse on "DUPA"

in Treatment 9 upvotes 6 months ago

The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

community Eliminating scalp itch leads to regrowth (and my RU58841 progress)

in Research/Science 63 upvotes 1 year ago

User experienced hair regrowth after eliminating scalp itch with RU58841. Others discussed itch and hair loss connection, and effectiveness of combining RU58841 with 5AR inhibitors.

community The hardest hair protocol ever!

in Research/Science 10 upvotes 2 years ago

The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

community Sharing my progress over the years, also some recent struggle on RU58841 and crazy shed.

in Progress Pictures 48 upvotes 1 year ago

Matt-3422 shared his hair loss treatment journey, starting with great results from Minoxidil and oral Finasteride, then switching to RU58841 and topical Finasteride due to worsening hair loss. He's experiencing scalp irritation and is unsure if he should continue with his current regimen, while others suggest scalp care and alternative treatments.