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Glossary Genetic Testing

analyzing DNA to identify genetic mutations or predispositions

Genetic testing, also known as DNA testing or genetic screening, involves analyzing an individual's DNA to identify changes or mutations that may indicate a risk for certain genetic disorders or diseases. This process can help diagnose conditions, guide treatment decisions, and inform individuals about their genetic predispositions, including those related to hair loss and alopecia.

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community DNA Testing by Roots by Genetic Arts

4 upvotes 2 years ago

A user shared their positive experience with Roots by GA, a company that creates personalized hair loss treatments based on DNA analysis, which confirmed their inability to tolerate finasteride. The user is satisfied with their progress 30 days after a hair transplant and the customized formula they received.

community Is trichogram a good thing for testing genetic hair loss

2 upvotes 6 months ago

A dermatologist checked for hereditary hair loss using blood tests and plans to perform a trichogram. The user had slightly low Vitamin D3 levels, and the trichogram may help confirm androgenetic alopecia.

community Pre Finasteride Treatment, is testing for free DHT necessary?

4 upvotes 3 years ago

The conversation is about whether testing for free DHT is necessary before starting Finasteride for hair loss, despite having other hormone tests available. One person suggests that genetic response to DHT is more important than DHT levels and advises starting Finasteride without the free DHT test.

community My 200IQ genius master plan for dirt cheap dutasteride - can anyone see flaws to this plan?

11 upvotes 3 weeks ago

The conversation discusses a plan to test cheap generic Dutasteride capsules from India for authenticity using a UK drug testing service, WEDINOS, to identify reliable options for cost-effective hair loss treatment. Concerns are raised about the consistency and reliability of these generics, even if initial tests show they contain Dutasteride.

community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 1 year ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

community Why Is No One Talking About Chromosome 20?

in Chat 32 upvotes 1 year ago

Some hair loss may be linked to chromosome 20, which isn't affected by DHT blockers like finasteride. Treatments like minoxidil, microneedling, and genetic testing are suggested, but their effectiveness for this type of hair loss is uncertain.

community Miniaturization(?) after 12 months on oral fin/min compound

13 upvotes 1 month ago

After 12 months on an oral compound of finasteride, minoxidil, and biotin, the user experienced a seasonal shed and noticed thinner hairs at the hairline, raising concerns about ongoing miniaturization. Another user shared a similar experience and mentioned switching to dutasteride after genetic testing showed finasteride was ineffective.

community Genetic variations associated with response to Dutasteride. Why is it never mentioned?

in Research/Science 26 upvotes 1 year ago

Genetic variations influence how people respond to dutasteride for hair loss, with some benefiting more from finasteride. Dutasteride is effective for most, but genetic differences may cause it to be less effective for some.

community PP405 gets its generic name - Suvomipic

287 upvotes 1 month ago

Suvomipic, previously known as PP405, is progressing to Phase 3 trials for hair loss treatment. Its effectiveness compared to existing treatments like Minoxidil and Finasteride is still uncertain.

community Unexpected Serum DHT Elevation after Generic Dutasteride Use.

in Finasteride/Dutasteride 38 upvotes 1 year ago

Switching from finasteride to a generic dutasteride led to unexpectedly high DHT levels, prompting a switch to a reputed brand and consideration of softgel capsules for better absorption. The user plans to retest DHT levels and may return to finasteride if issues persist.

community PP405 (JXL069) Is Confirmed: Here’s Everything I’ve Learned After a Year of Testing

80 upvotes 1 month ago

JXL069, also known as PP405, did not lead to hair regrowth after a year of testing. The lack of results may be due to formulation issues, leading to a final attempt with an improved vehicle.

community Minoxidil aint shit, genetics are dumb, i dont want to be bald

in Minoxidil 217 upvotes 11 months ago

Minoxidil alone is not effective for significant hair regrowth; combining it with finasteride or dutasteride is necessary. Additional treatments like hair transplants, microneedling, or oral medications are recommended for better results.

community Do we know exactly why some people respond so great to dut/fin,min and others dont?

in Research/Science 29 upvotes 1 year ago

Genetic factors, enzyme activity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.

community How is scalp sensitivity even measured?

in Research/Science 9 upvotes 8 months ago

There are no tests to determine genetic follicle sensitivity for hair loss, and conclusions are based on hypothetical or post-balding observations. Finasteride is mentioned as an easy, consistent treatment option compared to natural treatments.

community PSA: Not all Finasteride generics are created equal, effectiveness and severity of side-effects can vary by manufacturer.

1 year ago

Switching generic finasteride manufacturers can reduce side effects while maintaining effectiveness. Different fillers in generics may affect bioavailability and cause varying side effects.

community Getting PP405. Now…. or as soon as possible

147 upvotes 1 year ago

People are discussing obtaining and testing PP405 for hair loss treatment, with concerns about its purity and effectiveness. Some are considering delaying hair transplants, while others suggest using existing treatments like finasteride and minoxidil.

community What the hell does it mean by “do not apply to front of scalp”

in Minoxidil 24 upvotes 1 year ago

Minoxidil can be applied to the entire scalp, including the hairline, despite labels suggesting otherwise due to lack of specific testing. For best results in treating hair loss, combining minoxidil with finasteride is recommended, as finasteride addresses the underlying cause of male pattern baldness.

community RU58841 yakında elimde olacak Türkiyede bunu isteyen kimler var? ( I’ll have RU58841 in hand soon; who in Türkiye is interested in it?)

in Finasteride/Dutasteride 4 upvotes 1 month ago

The conversation is about sourcing RU58841 in Türkiye, with the original poster sharing their positive experience using it for hair loss, noting it reduced shedding without side effects. They plan to distribute it after lab testing, considering customs and pricing challenges.

community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.

in Finasteride/Dutasteride 52 upvotes 3 years ago

Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.

community Is Harry Kane on fin? His hairline seems constantly the same for years

28 upvotes 6 days ago

Harry Kane's hairline appears stable despite his family history of baldness, leading to speculation about his use of finasteride or other treatments. Some users discuss similar cases of slowed or halted hair loss in other individuals, attributing it to genetics or potential treatments.

community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 11 months ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

community Sugar and Hair loss connections

in Research/Science 41 upvotes 1 year ago

High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

community 2Y 5M on dut, ask me anything

in Finasteride/Dutasteride 130 upvotes 1 year ago

A user experienced significant hair regrowth using dutasteride without side effects, starting with finasteride and not using minoxidil or dermarolling. They attributed success to a unique genetic response to DHT blockers but did not share their full regimen, frustrating others.

community 35M Hair Loss Treatment Update

94 upvotes 4 days ago

A 35-year-old male shares his successful hair loss treatment using 1x foam Minoxidil (Rogaine), 1mg oral Finasteride, 2x weekly Keto Shampoo 5%, and a derma roller, with no side effects reported. He applies Minoxidil once daily before bed and attributes his hair loss to genetics.

community A warning to anyone considering 3rd party sourcing PP405 or its analogs

30 upvotes 5 months ago

Be cautious when sourcing PP405 or its analogs from third-party suppliers due to potential safety risks and lack of regulatory approval. The conversation highlights concerns about counterfeit products and the absence of reliable testing, making it risky to use such treatments.

community Is Amazon Minoxidil 5% Legit? Never seen it before

35 upvotes 1 month ago

Amazon's Minoxidil 5% is considered legitimate by some users, though availability varies by country. Users discuss differences in application for men and women, with some expressing skepticism about Amazon's products and recommending tests for authenticity.

community Bryan Johnson used a customized formula by Roots byGA to restore his hair

25 upvotes 1 year ago

Bryan Johnson used a customized hair restoration formula from Roots byGA, which includes Minoxidil, Cetirizine HCl, Latanoprost, Dutasteride, Melatonin, Caffeine, Tretinoin, Vitamin D3, and Vitamin E. Many users are skeptical of the effectiveness and uniqueness of the treatment, suggesting that standard treatments like Minoxidil and Dutasteride are more reliable.

community 1.5 Year - Bad Results (HT, FIN, MINO, PRP, etc)

64 upvotes 2 years ago

A user shared their disappointing results after 1.5 years of hair treatments, including a hair transplant, finasteride, minoxidil, PRP, vegan shampoo, and more. They are considering switching to dutasteride, oral minoxidil, and improving their microneedling routine.

community Attempting PP-405 topical gel reformulation

20 upvotes 1 week ago

A user is attempting to reformulate a topical gel using PP-405 for hair loss, aiming to enhance its effectiveness with additional compounds. They discuss the potential of PP-405 compared to other treatments like Minoxidil and GT20029, and emphasize the importance of proper formulation for efficacy.

community Hair Loss Causes Depression. Not Finasteride.

187 upvotes 7 months ago

Finasteride and Dutasteride do not cause depression or mood disorders; hair loss itself may be a more significant factor. Some users experience side effects from Finasteride, but it is generally well-tolerated.