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GlossaryFibrosis

formation of excess fibrous tissue, often causing scarring

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue as a reparative or reactive process. It often occurs as a result of chronic inflammation or injury, leading to scarring and potentially impairing the normal function of the affected area. For example, in the context of hair loss, fibrosis around hair follicles can prevent hair regrowth by disrupting the normal hair cycle.

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community Anti Fibrosis and Calcification regimen?

in Question 10 upvotes 6 years ago

The user experienced no improvement in hair loss with finasteride and minoxidil but had side effects. They plan to add wounding, scalp massage, vitamin K, and taurine supplements to their regimen and seek feedback on these additions.

community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 2 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Pirfenidone - The answer to fibrosis and baldness

in Treatment 19 upvotes 3 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

community You guys should check this out: the connection between cortisol, DHT, inflammation and fibrosis explained?

in Question 66 upvotes 5 years ago

The conversation discusses the effectiveness of finasteride and microneedling for treating hair loss. The linked article is seen as an advertisement for these treatments.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 2 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Could microneedling for the next 5 years cause any permanent damage?

in Microneedling 22 upvotes 1 year ago

Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scar tissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.

community Finasteride update/information on Penis/Penile Tissue

in Finasteride/Dutasteride 8 upvotes 1 year ago

Finasteride can reduce DHT in the genitalia, potentially causing side effects like reduced erections and penile fibrosis. Using PDE5 inhibitors like Tadalafil or Sildenafil may help maintain penile health and prevent fibrosis.

community The ultimate regiment to reverse hairloss

in Treatment 6 upvotes 1 year ago

The conclusion of the conversation is that the user "Shakalakaplaka" shares their comprehensive hair loss regimen, which includes various treatments targeting different pathways such as DHT, inflammation, fibrosis, immune system, testosterone, gut problems, and scalp health. The effectiveness of the regimen is not confirmed, and some users express skepticism or request before and after pictures for credibility.

community Well, I guess this puts the scalp tension theory to bed

in Satire 138 upvotes 2 years ago

Hair loss discussion includes various causes like DHT, blood flow, and skin fibrosis. Treatments mentioned are Minoxidil, Finasteride, and RU58841.

community Scalp Calcification - Inflamation

6 upvotes 5 years ago

A young male in his twenties discusses hair loss, mentioning the use of Minoxidil, topical finasteride, and occasional derma rolling. He inquires about scalp inflammation, fibrosis, and the potential benefits of magnesium oil and scalp massages for improving blood flow and hair health.

community Finasteride and natural topicals

in Finasteride 6 upvotes 6 years ago

A user reported hairline regrowth after two weeks on a treatment including finasteride, peppermint and rosemary oils, emu oil, magnesium oil spray, apple cider vinegar, and dermarolling, while avoiding shampoos and conditioners. They believe DHT contributes to hair loss but also suggest follicle fibrosis is an issue.

community Imo everyone should take serrapeptase for a short extended period to break up scar tissue in their scalp

in Research/Science 1 year ago

Treatments for hair loss, such as Minoxidil, Finasteride and RU58841, as well as using serrapeptase to break up scar tissue in the scalp.

community My scalp punch biopsy results🤔?

in Female 8 upvotes 1 year ago

Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

community 5 Month's progress on Topical FIN, MIN, Topical Dut, Laser Cap

in Progress Pictures 577 upvotes 3 years ago

User "hemantch" shares 5 months progress using topical Fin, Min, topical Dut, and a laser cap for hair loss. Significant regrowth was noticed after 1 month, and the treatments worked well despite being bald for 10 years.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 56 upvotes 3 days ago

community Exploring all options - Scalp tension theory

in Research/Science 9 upvotes 1 month ago

The conversation discusses the scalp tension theory as a potential factor in hair loss, alongside DHT, inflammation, and other mechanisms. Treatments mentioned include finasteride, minoxidil, and botox injections, with some users exploring additional methods due to varying effectiveness.

community 28M Hair Transplant in India, will update with results.

in Transplants 211 upvotes 8 months ago

A 28-year-old man had a hair transplant in India, choosing not to start finasteride due to past side effects with other medications but will use minoxidil for six months post-surgery. He researched and selected a clinic in Mumbai with a high reputation, underwent a 9-hour procedure for $965, and is optimistic about the results.

community Is it possible for androgenic alopecia to begin at early adolescent years?

in Chat 70 upvotes 1 year ago

Hair loss can begin in early adolescence and cause mental anguish. Treatments mentioned include eating cruciferous vegetables, engaging in physical activity, and maintaining scalp hygiene.

community Will hair regenerate if androgen receptors are nuked?

in Research/Science 9 upvotes 1 year ago

Treatments for hair loss, such as using AR receptor blockers and degraders, to see if follicles can regenerate in the long term. The conversation also discusses how hair transplants could be a potential solution.

community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community If the main mechanism of microneedling is an increase in bloodflow to the scalp, shouldn't we be pursuing other actions which increase bloodflow? Sauna, cold showers, high dosage fish oil, hard cardio, heme-iron(red meats), HAND STANDS, foods high in NO (arugula), ginger, increased water consumption

in Question 17 upvotes 5 years ago

Microneedling stimulates hair growth through stem cell activation during wound healing, not just increased blood flow. Other methods like showers or supplements don't replicate this effect.

community He used Dutasteride for 20 years. Interview

in Treatment 105 upvotes 3 days ago

community 6 MONTH PROGRESS - NO CHANGE AT ALL - Minoxidil/Daily Dermarolling/Vitamine D3

in Progress Pictures 12 upvotes 1 month ago

The user saw no hair regrowth after six months using minoxidil, daily dermarolling, and vitamin D3. Many suggest adding finasteride or dutasteride for better results.

community Microneedling monotherapy shown more effective at 0.5mm than 1mm and 1.5mm in recent 6 month study

in Microneedling 137 upvotes 2 months ago

Microneedling at 0.5mm is more effective than at 1mm and 1.5mm for hair loss. Users discuss switching to 0.5mm and combining it with Minoxidil.

community Scientists have found that a naturally occurring sugar in humans and animals could be used as a topical treatment for male pattern baldness | In the study, mice received 2dDR-SA gel for 21 days, resulting in greater number of blood vessels and an increase in hair follicle length and denseness

in Research/Science 634 upvotes 3 months ago

Scientists discovered a sugar gel, 2dDR-SA, that increased hair growth in mice. Users discussed its potential, comparing it to other treatments like Minoxidil and finasteride.

community 9 month update 1st slide 2020 at my worst vs today. 2nd slide 9 months ago vs today. 3rd, wet hair. 4th, hairline. 5th, damp hair. 6th crown view. 7th, brushed back. 8 & 9, hair in high Summer humidity. 10th, no lighting.

in Progress Pictures 342 upvotes 4 months ago

User shared 9-month hair regrowth progress using a Fin/Min spray from HIMS, with additional microneedling. Other users praised the results and discussed the effectiveness of topical treatments.

community Hair theory Scar tissue and Verteporfin

in Chat 25 upvotes 5 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community 7 months progress. fin 1.25 mg, oral min 2.5 mg, keto shampoo, micro-needling once per month. M/32

in Progress Pictures 82 upvotes 7 months ago

A user shared a 7-month hair loss treatment progress using finasteride 1.25 mg, oral minoxidil 2.5 mg, ketoconazole shampoo, and monthly micro-needling, noting denser hair and improved quality but no significant regrowth. They experienced mild testicular discomfort and heart palpitations, considering switching to topical minoxidil to avoid side effects.

community So does oral minoxidil age your skin or not

in Minoxidil 41 upvotes 7 months ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 8 months ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.