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GlossaryCross-Linking

chemical bonds form between polymer chains, enhancing material properties

Cross-linking refers to the process where chemical bonds are formed between different polymer chains, creating a network-like structure. This can increase the strength, stability, and rigidity of materials. In biological contexts, cross-linking can affect the properties of proteins and other macromolecules, influencing their function and interactions.

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community Is 2-deoxy-D-ribose (2dDR) good for human hair?

in Research/Science 9 upvotes 2 months ago

Topical 2-deoxy-D-ribose (2dDR) regrows hair in mice almost as well as 2% Minoxidil. However, 2dDR may contribute to oxidative stress and hair loss due to the formation of advanced glycation end products (AGEs).

community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.

in Minoxidil 11 upvotes 3 years ago

The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.

community Minoxidil and skin aging worry – which prevention methods (platelet rich plasma, microneedlig, mesotherapy, stem cells, co2, ultherapy, …)

in Chat 4 upvotes 2 years ago

User started minoxidil, noticed forehead lines and dark circles, and asked for non-invasive skin aging prevention methods. Another user suggested using tretinoin and hyaluronic acid for long-term benefits.

community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

128 upvotes 6 years ago

Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 5 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community Does whey protein and creatine aggravate hair loss?

in Research/Science 82 upvotes 11 months ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community We need to keep these snake oil companies accountable.

in Treatment 121 upvotes 5 months ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

community Nandrolone Replacement Therapy

in Treatment 41 upvotes 1 year ago

A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 8 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community How to BECOME a RESPONDER to Fin/Dut if you are not responding

in Finasteride/Dutasteride 305 upvotes 1 year ago

The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 month ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community What Works to Restore Hairloss for Cis-Males? Not Much

in Treatment 18 upvotes 4 years ago

Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

community First bottle of Morr-F arrived. Wish me luck, and an introduction.

11 upvotes 5 years ago

A user discusses their experience with hair loss and treatments, including minoxidil, micro needling, rosemary oil, dietary supplements, and topical finasteride (Morr-F). They emphasize the impact of lifestyle on hair health and express hope for improvement with the new treatment.

community Can’t do finasteride. Does this automatically cross out Pyrilutamide?

in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes finasteride intolerance and questioning if Pyrilutamide is an alternative. Pyrilutamide not commercially available, but may be tolerable if approved since it's not a 5aR inhibitor.

community How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR?

in Finasteride/Dutasteride 22 upvotes 4 months ago

Dutasteride and finasteride have similar risk profiles despite Dutasteride blocking more types of 5AR in the brain. Some users report no mood issues with either drug, and it is suggested that Dutasteride's larger molecular size may limit its ability to cross the blood-brain barrier.

community People who tolerate dut better than fin?

in Finasteride/Dutasteride 32 upvotes 1 month ago

Dutasteride may have fewer side effects than finasteride, with some users experiencing better hair maintenance. Experiences vary, with some preferring dutasteride for fewer side effects, while others see no significant hair improvement.

community Has anyone had issues on finasteride that resolved after switching to dutasteride?

in Chat 12 upvotes 1 year ago

Hair loss discussion includes finasteride issues resolved by switching to dutasteride. Specific treatments mentioned: Minoxidil, Finasteride, and RU58841.

community Oral Minoxidil in Europe (10 mg)

in Minoxidil 9 upvotes 3 months ago

The user is seeking oral Minoxidil in Europe due to issues with topical Minoxidil causing dandruff and dry scalp. They have started using oral Finasteride and are considering Ketoconazole shampoo.

community Great work done by the doctor (Hair transplant) Toronto Canada

in Progress Pictures 514 upvotes 6 months ago

A user shared progress pictures of a hair transplant done in Toronto, Canada. The conversation includes comments on the appearance of Antonio Conte, with some suggesting he looked better after shaving his head.

community I wanted to thank this sub for helping getting my hair back

in Progress Pictures 1731 upvotes 7 months ago

A user shared progress pictures showing hair regrowth after using 1mg finasteride daily, minoxidil foam twice daily, and dermarolling once a week for a year. Some commenters are skeptical about the authenticity of the before and after photos, joking about changes in appearance and questioning if it's the same person.

community Balding turned me into a Norwood mentalist

in Chat 253 upvotes 7 months ago

The conversation revolves around how balding has made the original poster and others hyper-aware of other men's hairlines, often judging the severity of their hair loss and whether they've had treatments like hair transplants, minoxidil, or finasteride. Some participants express a need for therapy due to their obsession, while others joke about their newfound "expertise" in assessing hair loss.

community 7 months update (min/fin) change to dut?

in Progress Pictures 89 upvotes 8 months ago

The user has been using finasteride and minoxidil for 7 months, seeing thicker hair but no temple regrowth, and is considering switching to dutasteride. Another person suggested trying microneedling on the temples before changing medications.

community Ru with gloves because of Systemic absorption?

in Research/Science 10 upvotes 11 months ago

The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemic absorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.

community Is there any Noticeable difference? Natural approach.

in Is this regrowth? 8 upvotes 11 months ago

The conversation discusses a natural approach to hair loss treatment using rosemary, peppermint oil, derma roller, pumpkin seed oil, and saw palmetto. Commenters note a slight or minor difference in hair growth.

community 22M Exact three months of medication. Dut(0.5mg/day)+minox(2 times a day)+vitamin D (60k/week)

in Progress Pictures 324 upvotes 2 years ago

User took Dutasteride, Minoxidil, and Vitamin D for hair loss treatment and saw improvement in 2 months. Vitamin D deficiency played a role in recovery.

community CB-03-01 supposed hair loss cure

in Treatment 7 upvotes 3 years ago

The conversation discusses why CB-03-01, a potential hair loss treatment, isn't widely discussed despite evidence of its effectiveness and safety. Some users mention other treatments like melatonin, procianidin b2, and RU58841, debating their effectiveness and safety.

community "Fluridil - As Good As RU58841 Without The Side Effects!?" ------ anyone here on fluridil?

in Technology 23 upvotes 3 years ago

Treatments for hair loss, such as Minoxidil, finasteride, RU58841 and Eucapil; the legitimacy of RU58841 products; and safety concerns related to using RU58841.

community Hair Cafe vid: low dose dutasteride ?

in Finasteride/Dutasteride 6 upvotes 2 months ago

The user is considering using 0.5 mg dutasteride once every 5 or 7 days due to side effects from finasteride and is also looking into topical liposomal dutasteride and pyrilutamide to stop hair loss. The goal is to stop hair loss, not regrow hair.

community Shedding on pyri (KX-826) is this normal?

in Update 8 upvotes 2 months ago

A user experienced increased shedding after adding KX-826 to their long-term finasteride and minoxidil regimen. Another user reported mild side effects from KX-826, such as stomach and testicle pain.

community Any early Kintor's KX-826 experiences?

in Research/Science 10 upvotes 3 months ago

The conversation is about experiences with Kintor's KX-826 for hair loss, specifically regarding side effects. Some users reported side effects from grey market versions, questioning their authenticity.