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GlossarycAMP response element-binding protein

regulates gene transcription in response to cellular signals

cAMP response element-binding protein (CREB) is a cellular protein that binds to specific DNA sequences called cAMP response elements, thereby regulating the transcription of certain genes. It plays a crucial role in various cellular processes, including the growth and survival of cells, by responding to hormonal signals and other external stimuli.

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community So what’s really the deal with dutasteride hairline ruining claims?

in Finasteride/Dutasteride 72 upvotes 2 years ago

The potential effects of dutasteride on hair loss, with some users reporting it improved their hairline while others experienced worsened hair loss or shedding. Other treatments discussed include minoxidil and finasteride, as well as RU58841.

community Guys on oral dut AND oral minox, what has been your experience so far?

in Chat 18 upvotes 2 months ago

Users discussed their experiences with oral minoxidil and dutasteride for hair loss. Most reported positive results, including hair regrowth and improved hair quality, with minimal side effects.

community Kevin if you can see this now, please don’t go.

in Chat 553 upvotes 5 months ago

Kevin, a YouTuber known for his channel "haircafe," helped many with hair loss through treatments like finasteride. He recently took down his channel and checked into a psych ward due to mental health issues and backlash over old posts.

community 1 year on Fin 1 mg. Switching to .4 mg Dut and oral 1.25 mg min

in Progress Pictures 451 upvotes 1 year ago

User shared 1-year progress on Fin 1 mg, switching to 0.4 mg Dut and oral 1.25 mg Min. Good results with Fin, biotin supplement, and biotin shampoo; trying Dut and oral Min for potential better results.

community Anagenic announces the launch Pyrilutamide on their website. Are you excited ?

in Treatment 80 upvotes 2 years ago

The launch of Pyrilutamide as a potential hair loss treatment, with people discussing whether it is better than treatments like finasteride and minoxidil. Some participants have also discussed the risks associated with importing drugs from China.

community Dental technician is convinced that he has found the cause of pattern hair loss

in Research/Science 314 upvotes 3 months ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community Should I get transplant #4 or just shave my head?

in Transplants 169 upvotes 3 months ago

A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

community Male pattern baldness, and mental health

in Finasteride/Dutasteride 330 upvotes 9 months ago

A 48-year-old man has been using minoxidil for 15 years and considered finasteride but stopped due to potential side effects. He is concerned about his mental health and the impact of hair loss on self-image, and he encourages support among men experiencing hair loss.

community Anyone else growing tired of the finasteride wars?

in Finasteride/Dutasteride 169 upvotes 1 year ago

The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

community This is the best time in human history to be fighting hair loss

in Treatment 193 upvotes 2 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

community Dutasteride (.5mg) is some strong stuff!

in Finasteride/Dutasteride 58 upvotes 2 years ago

User switched from finasteride and minoxidil to dutasteride, experienced side effects, then took dutasteride once a week with improved hair density. Another user had success with daily dutasteride, while one had no results from topical dutasteride.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community 1 year of minoxidil no sides - hows my collagen?

in Progress Pictures 16 upvotes 4 years ago

A user shared progress pictures after one year of using minoxidil with no side effects, asking about their collagen. Another user commented on the genetic aspect of hair loss.

community fin-min-keto-derma did not work for me. 24 yo

in Update 16 upvotes 3 months ago

A 24-year-old tried minoxidil, finasteride, keto shampoo, and derma-rolling for hair loss but saw no improvement and is now at Norwood 5. They feel there's nothing more they can do and are considering going bald despite not liking the look.

community Before/After 1 day topical minoxidil. Anyone else notice it gives you wrinkles and bags under your eyes?

in Satire 579 upvotes 1 year ago

This conversation discussed the side effects of Minoxidil for hair loss, with users sharing their experiences. Treatments such as Retinol and Tretinoin were suggested alongside topical or oral Minoxidil to reduce any negative impacts.

community 7 Months on 1.5mg of fin. 1st pic in March and 2nd one is from yesterday. Are these gains or is it because my hair is just longer?

in Progress Pictures 162 upvotes 6 months ago

A user shared progress pictures after 7 months on 1.5mg of finasteride, showing significant hair improvement. The user clarified they split 5 mg pills into quarters, resulting in a 1.33 mg dose.

community 3 month progress on Minoxidil 5% only.

in Is this regrowth? 1039 upvotes 6 months ago

A user is pleased with their hair regrowth after 3 months using Minoxidil 5%. They plan to start Finasteride upon returning home, and others discuss the importance of consistency and patience with hair loss treatments.

community It's not just about your hair, it's also about YOU!

in Chat 73 upvotes 1 year ago

The user has been on Finasteride and oral Minoxidil for hair loss and experienced minimal side effects. They suggest that a healthy lifestyle, including good sleep, exercise, diet, skincare, and mental health care, may help reduce the perceived side effects of Finasteride, although another user disagrees, emphasizing that side effects can vary and may not be mitigated by lifestyle alone.

community I feel like people here shrug off nutritional issues too quickly. Particularly for Retrograde Alopecia.

in Chat 9 upvotes 1 year ago

The user believes Retrograde Alopecia may be linked to vitamin imbalances, specifically from taking too much Vitamin E, A, Zinc, and Selenium, and suggests it could be a middle ground between Androgenic Alopecia and Telogen Effluvium. Treatments for hair loss mentioned include Androgen inhibitors and improving lifestyle factors like nutrition and sleep, with topical melatonin also recommended for Retrograde Alopecia.

community Pyrilutamide available at Actifolic now

in Research/Science 15 upvotes 2 years ago

Pyrilutamide, a new hair loss product with the potential to be more effective than RU58841 and safer than CB, but expensive.

community pyrilutamide phase 2 results right here, thanks to user Glaringbooch

in Chat 40 upvotes 2 years ago

Pyrilutamide, a new drug being tested to combat hair loss that has been found to perform comparably or better than finasteride and dutasteride in the initial 6 months of treatment with minimal reported side effects.

community Is it just me, or when people start having MPB symptoms, every single person you look at you start analyzing their hair? Ik it sounds weird

in Chat 168 upvotes 4 months ago

A user discusses their habit of analyzing others' hair due to their own hair thinning at 18. Another user mentions starting finasteride in 2010 and still having a full head of hair.

community Is it possible that dutasteride won’t make you depressedd if finasteride did?

in Chat 16 upvotes 7 months ago

The conversation discusses whether dutasteride might cause less depression than finasteride for hair loss treatment, with some users suggesting it could due to different mechanisms of action or molecular size, while others express skepticism or share personal experiences with these medications.

community How possible is temple regrowth really?

in Minoxidil 48 upvotes 8 months ago

A person started using finasteride, minoxidil, and dermarolling to regrow hair at the temples and is asking if it's possible. Some users report temple regrowth is possible with these treatments, while others find it challenging, and advise consistency and patience with treatment.

community 28M | topical finasteride (0.3%) minoxidil (6%) | 1.5 years progress

in Progress Pictures 826 upvotes 9 months ago

A 28-year-old man saw hair regrowth after 1.5 years using a topical treatment combining 0.3% finasteride and 6% minoxidil. He initially experienced anxiety with oral finasteride but had no side effects with the topical version.

community Can someone explain the Dutasteride hysteria in this community?

in Finasteride/Dutasteride 58 upvotes 1 year ago

The conversation is about the double standard in the hair loss community regarding shedding when using different treatments. The conclusion is that shedding is considered normal when starting finasteride or minoxidil, but not when starting dutasteride, despite the fact that dutasteride is more effective at reducing DHT.

community [M30] 15 months FIN + nizoral progress

in Finasteride/Dutasteride 526 upvotes 1 year ago

User experienced significant hair regrowth using 1.25mg Finasteride daily and Nizoral once a week for 15 months. Noticeable results appeared after 6 months, with no side effects reported.

community What’s the science behind 1mg Finasteride 3 X a week being as effective as daily?

in Finasteride/Dutasteride 19 upvotes 1 year ago

The efficacy of taking 1mg finasteride three times a week instead of daily for hair loss, with some users arguing that it is just as effective because finasteride has a long half-life in the scalp tissue and lower doses have been shown to be effective. Other users suggest experimenting with various treatments such as minoxidil and finasteride to achieve best results.

community Why Cant we just find an effective androgen receptor antagonist that works locally on the scalp?

in Research/Science 1 year ago

Researching and developing an effective local antagonist to block the androgen receptors for hair loss, as opposed to using DHT synthesis inhibitors that lower serum DHT levels. Several treatments such as CosmeRNA and Pyrilutamide are currently in development or undergoing trials.

community Rosemary oil, peppermint oil, mucuna pruriens - two weeks in

in Treatment 84 upvotes 1 year ago

A user who is trying alternative treatments, such as mucuna pruriens dissolved in water/alcohol and a blend of jojoba oil, rosemary oil, and peppermint oil, for hair loss. Other users have shared anecdotal evidence, discussed the potential effectiveness of certain treatments, and questioned the time sensitivity of experimenting with new treatments.