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Did you mean 5AR inhibitor?

Glossary5-alpha-reductase inhibitor (5AR inhibitor)

blocks enzyme converting testosterone to dihydrotestosterone (DHT)

A 5-alpha-reductase inhibitor is a type of medication that blocks the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, these inhibitors can help treat conditions like male pattern baldness and benign prostatic hyperplasia (BPH).

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community ghk-cu is potent 5-ar inhibitor?

in Product 9 upvotes 11 months ago

GHK-Cu is a potent inhibitor of the type 1 5-alpha reductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alpha reductase inhibitors. The user previously experienced side effects with 5-alpha reductase inhibitors and is considering GHK-Cu as an alternative.

community Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy

in Research/Science 2 upvotes 2 weeks ago

Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.

community What blood markers to get tested before starting any 5-AR inhibitor?

in Treatment 4 upvotes 8 months ago

The conversation is about which blood markers to test before starting a 5-AR inhibitor for hair loss. The user mentions already testing Total T, Free T, SHBG, Estradiol, Haematocrit, Red blood cell count, and White cell count, and asks if DHT or additional markers are needed.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 2 months ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community Genetics are so weird and unpredictable

in Minoxidil 118 upvotes 2 months ago

The user experienced male pattern baldness starting at 18, tried finasteride with no success, and switched to dutasteride, which halted hair loss. Minoxidil had no effect for them, while their brother, who didn't use AR inhibitors, maintained a juvenile hairline and successfully grew a beard with minoxidil, highlighting the unpredictable nature of genetics in hair loss and treatment response.

community Discussion: High DHT levels while on Fin+Dut with substantial progress (pics)

in Progress Pictures 63 upvotes 2 years ago

A user's experience with using 5AR inhibitors (Finasteride and Dutasteride) in combination with Minoxidil foam and microneedling, which resulted in substantial improvements to their crown density and hairline, despite high systemic levels of testosterone and dihydrotestosterone.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Blood DHT Levels – before and after creatine

in Research/Science 41 upvotes 1 year ago

The impact of creatine on DHT levels, and whether it could cause accelerated male pattern baldness (MPB). The user taking a 5 alpha reductase inhibitor found that their DHT levels actually reduced despite taking creatine for nine weeks. Replies suggested looking into testosterone levels as well and debating the safety of creatine use in relation to MPB.

community Hair follicle neogenesis

7 upvotes 9 years ago

A user plans to experiment with creating new hair follicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.

community How does Pyrilutamide compare to RU58841 when it comes to androgen receptor binding affinity?

in Research/Science 24 upvotes 2 years ago

The relative strength of Pyrilutamide compared to RU58841 in terms of androgen receptor binding affinity. It has been noted that Pyrilutamide is 4x stronger than RU58841, with a higher binding affinity than DHT itself.

community Is Keto shampoo 2% even worth starting?

in Ketoconazole 48 upvotes 4 months ago

Ketoconazole shampoo is primarily for scalp health and reducing inflammation, not hair regrowth. Combining ketoconazole with finasteride can yield similar results to using minoxidil and finasteride together.

community To everyone who cant use FIN and doesnt want to use RU

in Treatment 33 upvotes 5 months ago

A new hair loss treatment, KX-826, is being discussed as a stronger and safer alternative to RU58841 and finasteride. Opinions are mixed, with some users skeptical about its effectiveness and others considering it as part of their regimen.

community Has anyone tried the New Nordic Hair Gro tablets?

in Product 2 upvotes 1 year ago

The conversation discusses the effectiveness of New Nordic Hair Gro tablets for hair loss. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community Do we have anything in the pipeline that is used as a replacement for minoxidil?

in Minoxidil 15 upvotes 1 month ago

The conversation discusses hair loss treatments, focusing on alternatives to Minoxidil, such as Bimatoprost and Latanoprost, and the use of Finasteride, Dutasteride, RU58841, and microneedling. The user plans to add Latanoprost to their regimen, which already includes oral and topical Minoxidil and Finasteride, Ketoconazole shampoo, and microneedling.

community Can Fin + Min save my hair? [20M]

in Satire 3168 upvotes 6 months ago

A user is considering using finasteride and minoxidil to address hair loss, particularly at the temples and crown. Responses include encouragement, humor, and additional suggestions like using a derma roller.

community Thoughts on this Article: Post-Finasteride and Neurological Effects

in Finasteride/Dutasteride 14 upvotes 10 months ago

The conversation discusses the effects of finasteride on hair loss and its potential neurological and sexual side effects. Users share personal experiences, with some reporting positive outcomes and others expressing concerns about cognitive function.

community How to Keep Your Hair on Steroids

in Treatment 17 upvotes 4 months ago

To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.

community Got my tretinoin .025% script. Will keep you boys updated.

in Minoxidil 9 upvotes 2 months ago

The conversation discusses using tretinoin with topical minoxidil for hair regrowth, despite previous non-response to minoxidil and concerns about oral minoxidil's heart risks. The user is also on dutasteride and is considering a hair transplant if other options fail.

community The day they make a pill that only targets DHT production in the scalp

in Finasteride/Dutasteride 29 upvotes 2 months ago

Reducing DHT in the scalp is ideal for hair retention, with topical finasteride and dutasteride being common treatments. Some users report side effects like reduced libido, while others experiment with higher doses for regrowth.

community Well… I Did It. Estrogen Saved My Hairline

in Transgender 728 upvotes 4 months ago

OP transitioned and used Spironolactone, Estradiol Valerate, Minoxidil, and dermarolling, resulting in significant hair regrowth. They advise this method may not be suitable for cis men.

community Fin isn’t working anymore after 3 years, afraid to switch to dut?

in Finasteride/Dutasteride 27 upvotes 5 months ago

Finasteride stopped working for a user after 3 years, and they are considering switching to dutasteride. Other users suggest trying dutasteride, with some sharing positive experiences and additional treatments like minoxidil and RU58841.

community Dermatologist denied prescribing oral dutasteride because it’s not FDA approved BUT did prescribe ORAL minoxidil 😂

in Finasteride/Dutasteride 31 upvotes 6 months ago

A 22-year-old male has been using oral finasteride for a year with no improvement in hair loss and was denied dutasteride by a dermatologist due to FDA approval issues but was prescribed oral minoxidil instead. The user is seeking advice on whether to switch to dutasteride, continue finasteride, or add minoxidil.

community 2-month HMI-115 results from the Chinese trial

in Research/Science 69 upvotes 8 months ago

HMI-115 shows promising hair growth and thickening in just 2 months. Results are positive but need more time for confirmation.

community 1 year on fin. Take the pill. NOW.

in Progress Pictures 353 upvotes 9 months ago

After one year on finasteride, a user reports positive hair regrowth and minimal side effects, encouraging others to try the treatment despite potential risks. Other users share varied experiences with finasteride, some seeing improvements and others still waiting for results.

community 28M Hair Transplant in India, will update with results.

in Transplants 211 upvotes 10 months ago

A 28-year-old man had a hair transplant in India, choosing not to start finasteride due to past side effects with other medications but will use minoxidil for six months post-surgery. He researched and selected a clinic in Mumbai with a high reputation, underwent a 9-hour procedure for $965, and is optimistic about the results.

community It’s getting worse. (4 months)

in Update 203 upvotes 1 year ago

The conversation discusses hair loss treatments, with users suggesting the use of finasteride daily, considering minoxidil for aggressive hair loss, and discussing the normalcy of shedding during treatment. Some users recommend adding Nizoral shampoo and switching to dutasteride for better results.

community Is there any Noticeable difference? Natural approach.

in Is this regrowth? 9 upvotes 1 year ago

The conversation discusses a natural approach to hair loss treatment using rosemary, peppermint oil, derma roller, pumpkin seed oil, and saw palmetto. Commenters note a slight or minor difference in hair growth.

community Anecdotal, but: Adding RU58841 has stopped my Dutasteride shed

in Finasteride/Dutasteride 21 upvotes 1 year ago

Adding RU58841 to Dutasteride treatment helped reduce hair shedding significantly for several users. Some reported no change with RU58841, while others experienced a dramatic decrease in shedding and increased hair density.

community Are there ever going to be any oral DHT blocking treatments in the future?

in Product 6 upvotes 1 year ago

The discussion revolves around the need for future oral DHT blockers for hair loss treatment that don't have the side effects of current options like Finasteride and Dutasteride. One user suggests that the future of hair loss treatment will likely be topical anti-androgens, as they can target hair follicles without affecting the entire system.

community I'm gonna be bald by 20 and I'm not even exagerrating. Wtf do I even do?

in Chat 77 upvotes 1 year ago

A 16-year-old is experiencing early male pattern baldness and is considering using Minoxidil now and Finasteride after turning 18. Another user shared a positive experience with topical Minoxidil and Finasteride, noting improvement in hair thickness and no side effects.