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Did you mean androgenic adverse effects?

GlossaryAndrogenic Side Effects

involve physical changes due to male hormones like testosterone

Androgenic side effects refer to the physical changes and symptoms that occur due to the influence of androgens, which are male hormones like testosterone. These effects can include increased body hair, acne, deepening of the voice, and in some cases, hair loss (androgenic alopecia). These side effects are often seen with the use of anabolic steroids or other medications that affect hormone levels.

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community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 45 upvotes 4 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 5 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Finasteride vs Dutasteride, some helpfully info I put together as a physician

in Finasteride/Dutasteride 18 upvotes 9 months ago

The conversation discusses the pros and cons of dutasteride for male pattern baldness, with a focus on its long half-life. The user, a physician, also mentions that switching from finasteride to dutasteride can cause temporary hair loss until dutasteride reaches effective levels or accelerates the hair cycle.

community KX-826 Phase 3 Failed. Sorry guys...

in Research/Science 49 upvotes 10 months ago

The conversation discusses the failure of Phase 3 trials for the hair loss treatment KX-826, with no significant difference found between the drug and placebo. Some users express disappointment and skepticism, while others discuss alternative treatments like Minoxidil, finasteride, and RU58841.

community Does anyone here use everything except Fin

in Minoxidil 22 upvotes 10 months ago

The conversation is about hair loss treatments, specifically Minoxidil (Min) and Finasteride (Fin). The original poster is considering using Min and other treatments but is hesitant about Fin, while the responses vary, with some advocating for early use of Fin and others warning about potential side effects.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 5 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community Just had this wild thought come into my head.

in Satire 403 upvotes 7 months ago

The conversation is about the debate over the existence of Post-Finasteride Syndrome (PFS) and its symptoms, with some users skeptical about PFS and others discussing side effects like erectile dysfunction and gynecomastia from hair loss treatments like finasteride. Specific treatments mentioned include finasteride, viagra, and a joke about using a popsicle stick for erectile support.

community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

in Finasteride/Dutasteride 244 upvotes 1 year ago

The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.

community Testosterone and hair loss seeming irrelevance

in Research/Science 82 upvotes 1 year ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 1 year ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community Hey guys I’m in desperate need for opinions from long term finasteride users

in Finasteride/Dutasteride 25 upvotes 1 year ago

Whether taking finasteride and dutasteride can cause penile shrinkage, with long-term users providing their personal experiences.

community Kintor Phase 2 Results released KX-826 (pyrilutamide)

in Research/Science 451 upvotes 2 years ago

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 66 upvotes 3 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 41 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community The story of RU58841/ PSK3841

in Research 622 upvotes 1 month ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 2 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Debunking the "Adverse metabolic consequences of dutasteride"

in Research/Science 40 upvotes 3 years ago

Dutasteride is more effective than finasteride, has neuroprotective benefits, and may prevent acne. Despite initial concerns about metabolic effects, further research suggests it is safe for most users, especially if not hypogonadal.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 15 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Kintor has released an investor relations memo regarding Chinese Phase III trials for Pyrilutamide

in Update 53 upvotes 10 months ago

Kintor's Pyrilutamide (KX-826) showed hair growth in Chinese Phase III trials but did not significantly outperform placebo. The treatment was safe with no major adverse reactions reported.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 1 month ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 22 upvotes 3 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community I am putting my hair loss treatment on hold until my mental health is better.

in Update 18 upvotes 4 weeks ago

OP is pausing hair loss treatments to focus on mental health due to anxiety and side effects from RU58841. They plan to try topical finasteride and minoxidil after recovering from pneumonia.

community Very reluctantly starting Finasteride.

in Finasteride/Dutasteride 84 upvotes 7 months ago

A 23-year-old started taking 0.25 mg of Finasteride daily for hair loss after trying Minoxidil and derma rolling without success. People shared varied experiences with Finasteride, discussing potential side effects, effectiveness, and personal decisions regarding hair loss treatment.

community 5% Minoxidil after 4 months - started with twice a day but went down to once because I kept forgetting in the morning. Really happy with how it is going!

in Progress Pictures 438 upvotes 1 year ago

The conclusion of the conversation is that the user started using 5% Minoxidil for hair loss and is happy with the progress. They also mentioned being trans and coming off testosterone, which they believe will help prevent further hair loss. Some users suggested using finasteride as well.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 6 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Post Finasteride Syndrome, A dangerous lie.

in Chat 142 upvotes 7 months ago

A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.

community Yes, most models are absolutely on finasteride

in Finasteride/Dutasteride 1104 upvotes 8 months ago

The conversation discusses how many male models and celebrities likely use finasteride to prevent hair loss, with some expressing surprise that it's not just good genetics keeping their hair intact. Specific treatments mentioned include finasteride and, in one query, minoxidil.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 158 upvotes 9 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 129 upvotes 1 year ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.