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GlossaryAndrogen Receptor

protein in cells that binds male hormones to regulate genes

The androgen receptor (AR) is a type of protein found inside cells that binds to androgens, which are male hormones like testosterone and dihydrotestosterone. This binding activates the receptor, allowing it to enter the cell nucleus and influence the expression of specific genes, playing a crucial role in the development and maintenance of male characteristics, as well as in conditions like androgenic alopecia (male pattern baldness).

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community Found this meme on a forum……..

alittlelessconversa in Satire 150 upvotes 1 year ago

The conversation is about a meme related to hair loss that influenced someone to start taking finasteride. Another person agrees that the meme accurately represents the situation.

community Do People even realize that we got a new Treatment Option and Kintor Officially released Pyrilutamide?

Worth-Beat-1953 in Treatment 56 upvotes 6 months ago

A new hair loss treatment, Pyrilutamide, has been released and is claimed to be a strong anti-androgen, potentially effective when used with finasteride. However, there are mixed opinions on its effectiveness and safety, with some users skeptical and others purchasing it.

community Does CosmeRNA target the root cause of MPB?

CumsOnYourFeet69 in Chat 1 year ago

. CumsOnYourFeet69 has been discussing a new treatment called CosmeRNA which claims to target the root cause of male pattern baldness, and is considering using it in conjunction with Minoxidil instead of Finasteride due to possible side effects. Replies have highlighted that the efficacy of this treatment is still unknown, but it could be used as an effective maintenance option if successful.

community What do we actually know about HMI-115?

Shenanigan_n_again in Chat 16 upvotes 1 year ago

The post and conversation are about HMI-115, a potential treatment for hair loss. The conclusion is that HMI-115 is not a 5ar-inhibitor and is instead a prolactin receptor inhibitor. Some users are skeptical about its effectiveness and believe that baldness will still be a problem in the future.

community Concerns about CosmeRNA safety mechanisms

Civil-Negotiation27 in Treatment 3 upvotes 1 year ago

Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

community How long until pyrilutamide or gt20029 get FDA approved?

Known-Care-271 in Research/Science 7 upvotes 1 year ago

Hair loss treatments pyrilutamide and GT20029 discussed. Pyrilutamide approval in 2 years, GT20029 in 5-6+ years.

community Shaved my head after 7 years of fighting hair loss

notnicethrow in Shaved/buzzed 52 upvotes 1 year ago

A user's decision to shave their head after struggling with hair loss for seven years, and the medications and treatments they are using to attempt regrowth. They also discuss potential future treatments that may come out in the near future.

community Hair loss and ethnicity - Caucasian men the most likely to experience hair loss

Dvine24hr in Chat 17 upvotes 2 years ago

The conversation discusses how Caucasian men are more likely to experience hair loss due to genetic predisposition, with factors like the androgen receptor on the X chromosome playing a significant role. The user also expresses confusion about the evolutionary reasons for hair loss, especially in colder climates where it would seem beneficial to retain hair for warmth.

community First patient dosed with Pyrilutamide (Kintor) Phase III

jamesKaoss in Research/Science 201 upvotes 3 years ago

First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

community It’s over. NOTHING has worked.

thejaketor in Chat 95 upvotes 2 years ago

A user who has been trying various treatments for hair loss for four years, with no success. Suggestions include use of minoxidil, finasteride, RU58841, microneedling, supplements and multivitamins, lifestyle changes, scalp biopsy, and SMP.

community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

ThrowRA1212121211212 in Chat 1 year ago

This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

community why isn’t RU / pyri blamed for feminization, whereas spiro is?

manbearpot in Treatment 1 year ago

User asks if spironolactone can stack with finasteride and pyrilutamide for hair loss treatment. They question why spironolactone is associated with feminizing effects, while RU/pyri/fluridil, which work similarly, are not.

community Maintaining hair until Breezula without Fin

hairgodshavemercy in Treatment 6 upvotes 4 years ago

A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

community How to know if shedding is from tren or minoxidil?

thesausage58 in Minoxidil 5 upvotes 10 months ago

The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

community Progress: From June 2022 (7 months of min + fin) to now (1 year) — I’ve lost so much density in this period and I have no idea why. I was getting pretty good resultup until that point. Is there anything else I can try? I’ve tried min, fin, tretinoin, micro needling, and castor oil. I feel hopeless.

Throwaway_inator in Progress Pictures 11 upvotes 2 years ago

The user lost hair density after 7 months of using minoxidil and finasteride and is seeking advice on other treatments after trying tretinoin, microneedling, and castor oil. Suggestions include checking for scalp conditions like eczema or psoriasis, changing minoxidil brands, and questioning hair dryer use and finasteride dosage.

community I really hate how current hair loss treatment only rely on DHT blockers

Significant_Web1562 in Finasteride/Dutasteride 76 upvotes 1 year ago

The conversation discusses dissatisfaction with current hair loss treatments that mainly focus on DHT blockers like finasteride and dutasteride. Alternative treatments mentioned include RU58841, pyrilutamide, minoxidil, rosemary oil, and future possibilities like hair cloning.

community Scientific evidence for Peppermint & Rosemary oils + My Experience

Divallo in Research/Science 114 upvotes 2 years ago

Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

community Pattern hair loss could be due to gut bacteria

Paarebrus 48 upvotes 5 years ago

Feeding bacteria-free mice with Lactobacillus murinus worsened hair loss, but a regular diet with biotin stopped it. The conversation suggests gut bacteria and diet may influence hair loss, with some skepticism and discussion about other factors like DHT and genetics.

community Used finasteride 10 years ago and I still suffer from severe ED. I have blood test results attached

fappoo11 in Finasteride 10 upvotes 6 years ago

A user took finasteride for hair loss 10 years ago, stopped after a month, and has since suffered from severe erectile dysfunction (ED) and other symptoms. They shared blood test results seeking advice for their condition, and others discussed similar experiences with finasteride and related drugs.

community ASC-J9: Poor man’s GT-20029 that might work for regrowth. Anyone try this stuff?

BatWithTheGat in Research/Science 2 years ago

The potential hair regrowth benefits of ASC-J9, a synthetic modified version of curcumin that is said to be more effective than Minoxidil and Finasteride. Reports from users suggest good thickening and temple regrowth with topical use at 0.025% concentration.

community Testosterone and DHT levels through the roof yet has better hair than the majority of guys who are “healthy” genetics are everything

ZadarskiDrake in Satire 554 upvotes 1 year ago

The conclusion of this conversation about hair loss is that genetics play a significant role in determining hair loss, and specific treatments like finasteride may not be effective against certain compounds like masteron and trenbolone.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

Combfromhell in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community The story of RU58841/ PSK3841

Typical-Promise-3001 in Research 622 upvotes 5 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community My baby is balding! (Norwood 7)

danceandchance in Satire 1168 upvotes 1 year ago

The conversation is a satirical discussion about a baby with hair loss using adult hair loss treatments like finasteride, minoxidil, and ketoconazole, as well as dermarolling, scalp massages, and plans for PRP sessions. Suggestions include various other treatments and humorous advice, reflecting the satire of the situation.

community Finasteride vs Dutasteride, some helpfully info I put together as a physician

WellnessWisdomDrWang in Finasteride/Dutasteride 18 upvotes 1 year ago

The conversation discusses the pros and cons of dutasteride for male pattern baldness, with a focus on its long half-life. The user, a physician, also mentions that switching from finasteride to dutasteride can cause temporary hair loss until dutasteride reaches effective levels or accelerates the hair cycle.

community 16month progress on crazy stack

Foreign_Fondant_2880 in Finasteride/Dutasteride 8 upvotes 1 year ago

The user has been using a strong combination of hair loss treatments for 16 months, including Finasteride, Minoxidil, Dutasteride, and RU-58841, but their hair loss has worsened. They're questioning whether their high testosterone levels or residual scalp DHT are causing further hair loss, with a reply suggesting that even small amounts of DHT can cause hair loss if one is sensitive to it.

community How does Pyrilutamide compare to RU58841 when it comes to androgen receptor binding affinity?

Magiccity79 in Research/Science 24 upvotes 2 years ago

The relative strength of Pyrilutamide compared to RU58841 in terms of androgen receptor binding affinity. It has been noted that Pyrilutamide is 4x stronger than RU58841, with a higher binding affinity than DHT itself.

community Anyone still waiting on Pryiltamide order

Tall-Stick in Chat 2 upvotes 5 months ago

The user is frustrated with the delayed delivery of their Pryiltamide order from Koshine. They mention the order was shipped on August 23 but have received no updates since.

community Fluridil downregulates androgen receptor expression?

IllIssue229 in Research/Science 1 upvotes 1 year ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

rhguven in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.