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GlossaryAllopregnanolone

neurosteroid derived from progesterone that modulates brain activity

Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

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community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 127 upvotes 4 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Dutasteride mesotherapy could practically cure the world of balding.

in Treatment 51 upvotes 4 years ago

Dutasteride mesotherapy showed increased hair density and diameter without reducing serum DHT levels in a small study. However, the sample size was too small to make definitive claims about its efficacy.

community Where does time go? Turning 30 soon and been on treatment for 8 years.

in Update 267 upvotes 3 years ago

User started fin/min/niz at 23, switched to Dut at 24, and has been on treatments for 7 years. Despite occasional doubts, hair improved and user advises sticking with treatments.

community I've been afraid to start Finasteride treatment for 5 years, on it for 2 weeks, regret that hadn't started it earlier and here's my story

in Finasteride/Dutasteride 31 upvotes 3 years ago

A 28-year-old male, losing hair since his teens, started taking 0.31 mg finasteride daily for two weeks with no side effects and regrets not starting earlier. He tried various treatments like minoxidil, scalp massages, and vitamins but found finasteride most effective.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 11 months ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 46 upvotes 6 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community A Summary of the Latest Research regarding PFS, and How Supplementing Allopregnanolone Might Protect Against It

in Chat 6 upvotes 8 months ago

Post Finasteride Syndrome (PFS) may result from epigenetic changes and gut microbiota alterations. Supplementing with Allopregnanolone might protect against these adverse effects.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 4 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Why isn't anybody on topical bicalutamide?

in Research/Science 2 upvotes 5 months ago

Topical bicalutamide is discussed as a potential hair loss treatment. Other treatments mentioned include Minoxidil, finasteride, and RU58841.

community Debunking the "Adverse metabolic consequences of dutasteride"

in Research/Science 40 upvotes 3 years ago

Dutasteride is more effective than finasteride, has neuroprotective benefits, and may prevent acne. Despite initial concerns about metabolic effects, further research suggests it is safe for most users, especially if not hypogonadal.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 74 upvotes 4 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Checking in with my post-fin symptoms

in Finasteride 6 upvotes 8 years ago

A user reports persistent sexual side effects three months after stopping finasteride, despite a healthy lifestyle and supplements. They express concern over the lack of libido and infrequent erections.

community My hair after 3 steroid cycles

in Progress Pictures 25 upvotes 4 months ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

community How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR?

in Finasteride/Dutasteride 22 upvotes 4 months ago

Dutasteride and finasteride have similar risk profiles despite Dutasteride blocking more types of 5AR in the brain. Some users report no mood issues with either drug, and it is suggested that Dutasteride's larger molecular size may limit its ability to cross the blood-brain barrier.

community how about progesterone cream?

in Research/Science 21 upvotes 6 months ago

Progesterone cream might help with hair loss by inhibiting DHT production and suppressing prolactin, which can increase DHT. Some dermatologists have used progesterone for hair loss treatment, and it has been effective, sometimes combined with minoxidil, finasteride, and hydrocortisone.

community 4600 - result 9 month - Dr. Carman

in Progress Pictures 255 upvotes 9 months ago

A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%

in Update 1 upvotes 1 year ago

PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 2 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community Progressive insomnia (treatment-resistant) due to Finasteride

in Finasteride/Dutasteride 7 upvotes 2 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

community For what it's worth, I just want to state that I also think that adding Dutasteride to Finasteride has made my hair worse

in Finasteride/Dutasteride 18 upvotes 3 years ago

A user shared that adding Dutasteride to Finasteride worsened their hair loss, despite initial improvements with Finasteride alone. Others in the conversation debated the effectiveness of Dutasteride, with some suggesting individual responses vary and others defending its proven efficacy for hair loss.

community Insomnia and Finasteride

in Finasteride/Dutasteride 7 upvotes 3 years ago

A user reports experiencing insomnia as a side effect of taking finasteride for hair loss, which takes 1 to 2 hours to fall asleep and results in only about 5 hours of sleep per night. They suspect the cause is related to the downregulation of neurosteroids due to finasteride.

community A warning to those using or thinking about using Dutasteride – Follow-up

in Finasteride/Dutasteride 18 upvotes 3 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community Breezula CB-03-01

in Treatment 11 upvotes 4 years ago

The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.

community Tried to get a finasteride prescription but doc says I'm too young and warned me of sides. I'm 22. Says I should only use minox.

in Finasteride 22 upvotes 4 years ago

A 22-year-old was advised by their doctor to use 5% minoxidil for hair loss instead of finasteride due to age and potential side effects. Other users suggested either persisting with the doctor or finding a new one, sharing mixed experiences with finasteride.

community The safest way to use finasteride - my research

in Finasteride 23 upvotes 7 years ago

The post discusses microdosing finasteride to minimize side effects while treating hair loss. The user also mentions using minoxidil, biotin, and ketoconazole.

community 4 months of topical minoxidil with derma rolling starting at month 2 - my review / experience

in Is this regrowth? 46 upvotes 3 weeks ago

The user has been using topical minoxidil and dermarolling for hair regrowth but is hesitant to start finasteride due to potential side effects. Many suggest adding finasteride for better results in addressing DHT-related hair loss.

community HT / Meds results are reverting, thinning, crazy shedding..

in Progress Pictures 161 upvotes 1 month ago

A user experienced significant hair shedding and thinning 10 months post-hair transplant despite using minoxidil and topical finasteride. They are considering switching to oral finasteride or dutasteride and are also dealing with scalp conditions like seborrheic dermatitis.

community Any finasteride users have a history of depression?

in Finasteride/Dutasteride 26 upvotes 2 months ago

The conversation discusses finasteride for hair loss, especially among those with a history of depression. Users shared mixed experiences, with some reporting no issues and others experiencing worsened depression.

community So it turns out Post Finasteride Syndrome was never real?

in Finasteride/Dutasteride 271 upvotes 3 months ago

Post Finasteride Syndrome (PFS) is debated, with some users reporting severe side effects from finasteride, while others believe these effects are rare or psychosomatic. Treatments discussed include finasteride, minoxidil, and RU58841.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 4 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.