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GlossaryActin Cytoskeleton

dynamic network of actin filaments supporting cell shape and movement

The actin cytoskeleton, also known as the actin filament network, is a dynamic structure composed of actin proteins that form filaments within cells. It plays a crucial role in maintaining cell shape, enabling cell movement, and facilitating various cellular processes such as division and intracellular transport. This network is essential for the structural integrity and functionality of cells, including those involved in hair growth and maintenance.

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community I’m someone who was supposed to be prematurely bald. My hair loss started at 15, I started finasteride at 17, switched to dutasteride at 18, now at 19 this is my situation, thoughts? I know my life wouldn’t be that different if I was bald, I just feel more confident with hair..

in Progress Pictures 198 upvotes 1 year ago

A user's journey with hair loss, starting with finasteride at age 17 and switching to dutasteride at 18. The post provides insight on how minoxidil helped initially but quitting it caused some regrowth that was regained when switching to dutasteride. There is also discussion about starting finasteride as young as 17 years old for those who may be worried about potential physical development issues.

community Action plan without finasteride

in Product 8 upvotes 1 year ago

A user shared their hair loss treatment plan using Revita tablets, Sulforaphane, Minoxidil, and microneedling, avoiding finasteride due to side effects. Replies suggest that without finasteride, the plan is unlikely to be effective, and recommend either using finasteride or shaving their head.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 4 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community We all regret not acting on hair loss sooner. What is something else we can prevent if we act now?

in Chat 94 upvotes 9 months ago

The conversation discusses the importance of early action in various aspects of life such as healthy eating, skincare, fitness, sleep, financial planning, and career development to prevent future health issues, regret, and financial hardship. Specific treatments mentioned include using sunscreen and tretinoin for anti-aging skincare.

community Finasteyd topical 0.025% minoxidil and caffeine action

in Progress Pictures 102 upvotes 3 weeks ago

The user "OP" uses a combination of topical minoxidil 5%, finasteride 0.025%, and caffeine to combat hair loss, with noticeable results over 5-6 months. Side effects include unwanted body hair growth and an itchy scalp, but no significant sexual side effects.

community Despite its straightforward mrchanism of action, it looks like pyrilitamide doesn't help regrow hair like finasteride does.

in Research/Science 6 upvotes 10 months ago

Pyrilitamide (KX-826) did not show significant improvement in hair count compared to placebo after 6 months. It's unclear if it can maintain hair at baseline.

community Seriously confused about minoxidil's method of action

in Minoxidil 6 upvotes 2 years ago

The conversation discusses confusion about how Minoxidil promotes hair growth compared to other substances like Menthol, which have similar actions. The user mentions personal positive results with peppermint oil extract and is currently trying L-citrulline for its vasodilation effects.

community To all the young guys on here - please take action when you see loss immediately. 17M, 7 weeks between both pictures

in Progress Pictures 7 upvotes 10 months ago

A young man regrets not starting finasteride treatment for hair loss sooner, noticing significant shedding just two months prior. He advises others experiencing early hair loss to act quickly and start treatment.

community 17M Need y’all’s help with topical I was prescribed and what action to take

in Treatment 1 upvotes 10 months ago

A 17-year-old male experiencing significant hair loss is using a prescribed topical treatment containing Minoxidil, Tretinoin, Dutasteride, and Latanoprost. He expresses concerns about the potential side effects of Dutasteride and oral Finasteride, and seeks advice on whether to continue with the treatment or consider alternatives.

community Start taking care of your skin and hair loss TODAY! I was telling myself I didn’t care, but I think the difference in my facial expression says it all. Take action asap before more permanent damage is done. I hope I can inspire some of you, because it’s so worth it. Not for others, for yourself! <3

in Progress Pictures 583 upvotes 2 years ago

User shared progress in treating hair loss and improving skin, using treatments like finasteride, minoxidil, RU58841, tretinoin, microneedling, and skin care regimen. Others commented on the impressive results and asked about costs and side effects.

community Cassiopea Announces FDA Submission of New Drug Application for Clascoterone Cream 1%, the First New Mechanism of Action for Acne in Nearly 40 Years

in Technology 29 upvotes 5 years ago

The conversation is about a new acne treatment cream called Clascoterone Cream 1%, which is the first new mechanism of action for acne in nearly 40 years. One person joked about hoping their face will be as clean as their bald head after using the cream.

community Can we have a thread that summarizes all treatments options in addition to the big 3 which we have some evidence for, their mechanism of action and whether they can be combined with the big 3(other than dermarolling)?

in Treatment 58 upvotes 6 years ago

The conversation discusses hair loss treatments beyond the commonly known three, focusing on separating effective treatments from myths. Dutasteride and low-dose oral Minoxidil are mentioned as having clinical evidence for increasing hair counts, but with potential side effects.

community Finasteride, Dutasteride, Pyrilutamide, RU58841 all accomplish the same thing in your body. Why skip around?

in Treatment 1 year ago

Hair loss treatments Finasteride, Dutasteride, Pyrilutamide, and RU58841 have different mechanisms of action. They can be used individually or stacked for better protection against hair loss.

community Best advice when it comes to MPB is don't be in denial

in Chat 24 upvotes 4 years ago

The conversation is about the importance of acting quickly against hair loss. The user shares their experience with androgenic alopecia and mentions using finasteride without improvement.

community Finasteride is giving me relief when I needed it the most

in Finasteride/Dutasteride 46 upvotes 11 months ago

A 22-year-old experiencing hair thinning started using finasteride and feels relieved for taking action against hair loss. Others in the conversation share similar experiences, finding comfort in trying treatments like finasteride and minoxidil, even if they don't fully stop their hair loss.

community Why it always be young guys with hair like this ask if they going bald?

in Satire 523 upvotes 2 years ago

Young guys with thick hair asking if they're going bald and people discussing early action for hair loss treatments like Minoxidil and Finasteride. Some users share their positive experiences with these treatments.

community RU58841 and impact onmale fertility?

in Chat 2 upvotes 3 months ago

The conversation is about the potential impact of RU58841 on male fertility, specifically regarding sperm concentration, total count, and motility. The user is curious about the likelihood of RU58841 reducing fertility based on its mechanism of action and comparisons to similar substances.

community I enjoy taking finasteride every day

in Finasteride/Dutasteride 241 upvotes 5 months ago

Users discuss their positive experiences with finasteride for hair loss, mentioning halted hair loss, hair regrowth, and improved self-esteem. Some express satisfaction in taking action against baldness, while others note increased libido and energy.

community Is it possible that dutasteride won’t make you depressedd if finasteride did?

in Chat 16 upvotes 5 months ago

The conversation discusses whether dutasteride might cause less depression than finasteride for hair loss treatment, with some users suggesting it could due to different mechanisms of action or molecular size, while others express skepticism or share personal experiences with these medications.

community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 8 months ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community important questions about RU58841

in Research/Science 3 upvotes 9 months ago

The user has been using finasteride for hair loss and is considering adding RU58841. They ask about RU58841's effectiveness, potential heart side effects, duration of action, dosage increase over time, transitioning to GT20029, and where to find the liquid form.

community The insanity of hair loss is blinding

in Chat 828 upvotes 11 months ago

The conversation revolves around the psychological impact of hair loss and various treatments. Participants discuss using Minoxidil (Min) and Finasteride (Fin), hair transplants, and therapy for mental health. Some also recommend immediate action at the first signs of hair loss and joining supportive communities.

community A Technical Question About Pyrilutamide

in Research/Science 5 upvotes 1 year ago

Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

community Hasson & Wong: Dr Jerry Wong FUT 2877 Grafts. Failed surgery. Possible negligence and illegal behaviour.

in Transplants 491 upvotes 1 year ago

A user who had FUT surgery for 2877 grafts with Dr Jerry Wong of Hasson & Wong that resulted in low growth and an abnormally wide scar, suggesting negligence by the doctor and possibly illegal behaviour by an unqualified technician. The post sparked discussion about seeking legal action, as well as criticism of the clinic's high cost.

community Good enough to judge anything from these pics or no? 25y.o, several years on propecia, started minoxidil 4 months ago

in Is this regrowth? 1 year ago

This user has been taking finasteride for several years and recently added topical minoxidil to their regimen, specifically targeting the area of hair loss. They are wondering if this was a wise course of action.

community I shaved it all off

in Shaved/buzzed 16 upvotes 3 years ago

The user decided to shave their head instead of pursuing a hair transplant or using drugs like minoxidil and finasteride. They are motivated to accept themselves as they are and feel more confident after taking this action.

community Anyone else on their first couple weeks of Propecia (Finasteride) feel like little hair farmers?

in Finasteride/Dutasteride 140 upvotes 4 years ago

Taking steps to improve hair loss through treatments such as finasteride, minoxidil and ketoconazole. People discussed their experiences and shared a sense of satisfaction from taking action to improve their condition.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

in Treatment 7 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community Is it true that most hair loss treatments fall into one of two categories? If not, what am I missing?

in Treatment 3 upvotes 6 months ago

Hair loss treatments are generally categorized as anti-androgens, like finasteride and RU58841, which prevent hair loss by targeting DHT, and growth stimulators, such as minoxidil, rosemary oil, microneedling, and LLLT, which promote hair growth by increasing blood flow and growth factors. The user is seeking to confirm these categories and understand if there are other treatments or mechanisms of action.

community For people with overly oily hair, does topical finasteride/dutasteride/antiandrogens (like RU or Pyrilutamide) reduce sebum overproduction?

in Finasteride/Dutasteride 6 upvotes 1 year ago

The conversation discusses whether topical finasteride, dutasteride, or antiandrogens like RU58841 can reduce sebum overproduction as an early indicator of their effectiveness in treating hair loss. It suggests that while hair growth may take months to observe, a decrease in oiliness could be a quicker sign of a product's action.