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Glossary Collagen Type VII

protein crucial for anchoring skin layers together

Collagen Type VII is a specific type of collagen protein that plays a crucial role in anchoring the outer layer of the skin (epidermis) to the underlying layer (dermis). It forms structures known as anchoring fibrils, which are essential for maintaining skin integrity and preventing blistering. Defects in Collagen Type VII can lead to a genetic condition called dystrophic epidermolysis bullosa, characterized by fragile skin that easily blisters and tears.

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Research

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research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

This study found that Gelatinase A activity is linked to the absence of type VII collagen during human fetal skin development, indicating its role in remodeling the basement membrane zone.

research Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells

1 citations , May 2024 in “Journal of Dermatological Science”

In this study, KC-AD-MSCs were found to increase COL7 deposition and anchoring fibril formation at the dermal-epidermal junction in a RDEB mouse model, suggesting potential for improving skin integrity in recessive dystrophic epidermolysis bullosa patients.

research Using proteomics to compare the molecular structures of sulfide and permeate-depilated sheepskins

January 2024 in “Collagen and leather”

This study observed that using an environmentally friendly bovine milk permeate effectively and cleanly removes wool from sheepskins without harming the skin, and results in smoother leather compared to traditional chemical methods.

research 1327 Effect of ginsenoside Rd on dermal epidermal junction in fibroblast

April 2018 in “Journal of Investigative Dermatology”

This study found that treating human dermal fibroblast cells with ginsenoside Rd increased the expression of mRNA associated with the dermal-epidermal junction, suggesting potential as an anti-aging cosmetic ingredient.

research Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids

14 citations , May 2022 in “Stem cell reports”

This study reported that human induced pluripotent stem cell-derived skin organoids, used to model epidermolysis bullosa, have an epidermal-dermal junction largely lacking type VII collagen, which is important for skin structure.

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community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Collagen peptides: Yay or nay?

5 upvotes 6 years ago

Collagen peptides may help with hair growth, but results vary; some users noticed less hair fall and improved nail strength. Minoxidil is suggested for regaining hair thickness lost from accutane.

community Collagen peptides(powder) i highly recommend

7 upvotes 1 year ago

Collagen peptides are recommended for hair and skin benefits, with users noting improvements in hair and skin health. However, evidence on their effectiveness for hair growth is inconclusive.

community 5 months on Fin 1 mg + biotin collagen daily supplement I think this is progress but idk and pls help me get more

5 upvotes 6 months ago

The user has been using 1mg finasteride and biotin-collagen supplements for 5 months, noticing some progress in hair regrowth. They also use various oils and shampoos, plan to start oral minoxidil, and seek advice on improving their hair care routine.

community Anybody else notice improved skin/collagen on Dutasteride

6 upvotes 3 years ago

User switched from finasteride to combination dutasteride and finasteride for hair density improvement. They noticed less hair shedding and more youthful skin, with a reply suggesting less DHT could increase elastin in skin.

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learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

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