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research Clinical development and management of adverse events associated with FGFR inhibitors

65 citations , September 2023 in “Cell Reports Medicine”

This review examined the common side effects of FGFR inhibitors like erdafitinib, pemigatinib, and futibatinib, and detailed strategies for managing them, highlighting that proactive monitoring and appropriate interventions can effectively mitigate these toxicities.

research Clinical Development of Topoisomerase-Interactive Drugs

10 citations , January 1994 in “Advances in pharmacology”

This review examines the role of topoisomerase-interacting drugs in cancer treatment and emphasizes the importance of understanding their mechanisms for clinical development, but it presents no new results.

research Development of optimized self-nanoemulsifying lyophilized tablets (SNELTs) to improve finasteride clinical pharmacokinetic behavior

15 citations , November 2017 in “Drug Development and Industrial Pharmacy”

This study found that the optimized finasteride-loaded lyophilized tablets using a self-nanoemulsifying drug delivery system improved bioavailability in human volunteers compared to the marketed finasteride product.

research Development and clinical evaluation of green tea hair tonic for greasy scalp treatment.

4 citations , February 2018 in “PubMed”

This study found that a hair tonic containing 2% green tea extract significantly reduced scalp sebum in 20 volunteers over 28 days without causing skin irritation, suggesting its effectiveness and safety for managing scalp greasiness.

research Development of Uniform Protocol for Alopecia Areata Clinical Trials

2 citations , November 2015 in “Journal of Investigative Dermatology Symposium Proceedings”

This article discusses the creation of Alopecia Areata Uniform Protocols by the National Alopecia Areata Foundation to standardize clinical trials for alopecia areata treatments and reports no new results.

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community I built a tracker for every hair loss treatment in clinical development

in Research/Science 92 upvotes 8 months ago

A user created a tracker for hair loss treatments in clinical development, including compounds like Dermaliq, RU58841, and Pyrilutamide. The tracker updates with new information and allows filtering by conditions like androgenetic alopecia (AGA) and alopecia areata (AA).

community Amplifica Raised $26 Million to Continue Trials

in Research/Science 9 upvotes 1 month ago

Amplifica raised $26 million to advance its injectable treatments for hair growth. The funding will support the clinical development of their novel therapies.

community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

114 upvotes 1 year ago

The conversation discusses the potential of PP405 as a hair loss treatment, with some users expressing skepticism and others hopeful about its development. There is also mention of other treatments like Minoxidil, Finasteride, and Pyrilutamide, with users debating the effectiveness and safety of self-experimentation versus waiting for clinical trial results.

community US FDA will now default to only one clinical trial for drug applications, will this accelerate the release of PP405 and other drugs in clinical trials?

13 upvotes 7 months ago

The FDA will now require only one clinical trial for drug approval, potentially speeding up the release of hair loss treatments like PP405. Pelage is expected to present full results of PP405 Phase 2a trials and move to Phase III in mid-2026.

community Any treatments in development that could theoretically give complete regrowth?

in Research/Science 8 upvotes 1 year ago

New hair loss treatments like PP-405, AMP-303, and SCUBE3 are being discussed, but none are confirmed to fully restore hairlines. Current treatments like Minoxidil, Finasteride, and RU58841 are still widely used, with some hope for future advancements in hair regrowth.

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Learn

8 / 22 results

learn Pyrilutamide

Experimental topical anti-androgen, also known as KX-826

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

learn Follistatin

Protein that blocks activin, a growth-regulating signal

Are there any clinical studies supporting follistatin as a hair loss treatment? There is no controlled human trial showing follistatin treats hair loss; the published work is mouse and laboratory biology on the activin/follistatin signalling system, plus one small 2011 phase 1 injection study of a combination product, so follistatin remains experimental and unapproved.

learn Minoxidil

Vasodilator used on the scalp and, at low doses, as a tablet

learn SCUBE3

Signalling protein made in the hair follicle

What do clinical trials say about the safety and effectiveness of SCUBE3 for hair regrowth? No clinical trial of SCUBE3 for hair regrowth has been registered on ClinicalTrials.gov or published, so there is no human safety or effectiveness data. The evidence is limited to one 2022 laboratory and mouse study reporting that SCUBE3 activates hair follicle stem cells through TGF-beta signalling.

learn KY19382

Are there clinical studies showing that KY19382 can regrow hair in androgenic alopecia? No clinical studies have proven KY19382 regrows hair in androgenic alopecia.

learn Tofacitinib

What types of hair loss conditions are most commonly associated with tofacitinib use in clinical settings? Published studies link tofacitinib mainly to alopecia areata and its severe variants — as an off-label drug being studied for them, not as a cause of hair loss. The evidence is mostly small, open-label or retrospective, and relapse after stopping is commonly reported.

learn GT20029

When will GT20029 be commercially available, and are there any clinical trials on its use? GT20029 is investigational and not approved or sold anywhere. A published 12-week Phase II study in 180 Chinese men reports hair-count gains over placebo with two of four regimens, but no long-term or Phase III data exists, so any launch is years away at best.

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