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Glossary Chronic Leg Ulcers

long-lasting leg sores that don't heal within six weeks

Chronic leg ulcers are long-lasting sores or wounds on the legs that fail to heal within a typical timeframe, usually defined as six weeks or more. They are often caused by underlying conditions such as poor blood circulation, diabetes, or venous insufficiency, and can lead to significant pain, infection, and reduced quality of life if not properly managed.

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Research

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research Regeneration of Chronic Wounds with Allogeneic Platelet Gel versus Hydrogel Treatment: a Prospective Study

25 citations , January 2018 in “Acta Clinica Croatica”

This study found that allogeneic platelet gel significantly improved healing in non-healing chronic lower leg ulcers compared to hydrogel treatment.

research LB1154 Rising antimicrobial resistance in chronic wounds

July 2025 in “Journal of Investigative Dermatology”

DACC-based dressings are more effective than silver-based ones for treating chronic wounds with antimicrobial resistance.

research Skin grafting for the treatment of chronic leg ulcers – a systematic review in evidence‐based medicine

56 citations , March 2016 in “International Wound Journal”

This review concludes that autologous split-thickness skin grafting remains the gold standard for safety and efficacy in treating chronic leg ulcers, with greater success in venous ulcers.

research Klinefelter syndrome and chronic leg ulcers

February 2009 in “Journal of The American Academy of Dermatology”

A man with Klinefelter syndrome had a leg ulcer that didn't heal well, even with treatment.

research Hair-follicle Transplant Into Chronic Ulcers: A New Graft Concept

6 citations , June 2017 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

This study reported that using hair follicles from the scalp in punch-type grafts improved healing in chronic venous ulcers compared to traditional hairless punch grafts.

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community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 1 year ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

community M 25, 3.5 months apart images, fin works,

in Progress Pictures 278 upvotes 1 year ago

A 25-year-old male experienced hair regrowth after switching from topical minoxidil to a combination of topical minoxidil and oral finasteride, along with microneedling and multivitamins. He reported no significant side effects from finasteride, except mild discomfort, and emphasized the effectiveness of oral finasteride over topical solutions.

community Ultimate Stack without nuking your gender (you'll go broke)

86 upvotes 1 year ago

A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

community Could creatine trigger faster hairloss?

29 upvotes 2 years ago

Creatine is reported by many to increase hair loss, though no scientific evidence supports this. Some use finasteride and minoxidil to manage hair loss, while others avoid creatine due to personal experiences.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

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