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    Did you mean Chronic Leg Ulcers?
    Glossary Chronic Leg Ulcers

    long-lasting leg sores that don't heal within six weeks

    Chronic leg ulcers are long-lasting sores or wounds on the legs that fail to heal within a typical timeframe, usually defined as six weeks or more. They are often caused by underlying conditions such as poor blood circulation, diabetes, or venous insufficiency, and can lead to significant pain, infection, and reduced quality of life if not properly managed.

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    1. Regeneration of Chronic Wounds with Allogeneic Platelet Gel versus Hydrogel Treatment: a Prospective Study Acta Clinica Croatica · 2018 · 25 citations
    2. LB1154 Rising antimicrobial resistance in chronic wounds Journal of Investigative Dermatology · 2025
    3. Skin grafting for the treatment of chronic leg ulcers – a systematic review in evidence‐based medicine International Wound Journal · 2016 · 56 citations
    4. Ankle Range of Motion, Leg Pain, and Leg Edema Improvement in Patients With Venous Leg Ulcers JAMA Dermatology · 2016 · 4 citations
    5. Hair follicle stem cells: Walking the maze European Journal of Cell Biology · 2007 · 165 citations
    6. Reflections on how wound healing-promoting effects of the hair follicle can be translated into clinical practice Experimental Dermatology · 2014 · 43 citations
    7. Skin disorders in elderly subjects International Journal of Dermatology · 2015 · 27 citations
    8. Topical application of cellulose membrane for the treatment of non-healing venous leg ulcers Frontiers in Bioengineering and Biotechnology · 2026
    9. Self-Assessment Elsevier eBooks · 2019
    10. Obesity and the skin: Skin physiology and skin manifestations of obesity Journal of The American Academy of Dermatology · 2007 · 405 citations
    11. Pathologies of the skin and its appendages in endocrine diseases Dermatology Review · 2016
    12. The Efficacy of Local Autologous Platelet-Rich Plasma Prepared by Single and Double Spin Methods in the Treatment of Chronic Ulcer Cureus · 2024 · 2 citations
    13. Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective International Journal of Molecular Sciences · 2023 · 188 citations
    14. Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways International Journal of Nanomedicine · 2025 · 5 citations
    15. Zinc in skin pathology and care Journal of Dermatological Treatment · 2006 · 35 citations
    16. Innovative Uses for Zinc in Dermatology Dermatologic Clinics · 2010 · 27 citations
    17. Interrelation of immunity and tissue repair or regeneration Seminars in Cell & Developmental Biology · 2009 · 252 citations
    18. Skin Elsevier eBooks · 2011 · 2 citations
    19. Dermatology 2004 · 1 citations
    20. Geriatric Dermatologic Therapy 2026
    21. Guidelines for the prevention of lower extremity arterial ulcers Wound Repair and Regeneration · 2008 · 19 citations
    22. Enhancing Lower Extremity Defect Coverage: High Viability Ultra-Thin Split-Thickness Skin Grafts Obtained from the Scalp Journal of clinical medicine · 2023 · 2 citations
    23. Use of Leukocyte Platelet (L-PRF) Rich Fibrin in Diabetic Foot Ulcer with Osteomyelitis (Three Clinical Cases Report) Diseases · 2018 · 38 citations
    24. Microbial allies in skin trauma recovery: from immune modulation to engineered probiotic therapeutics Burns & Trauma · 2025
    25. Obesity and Wound Healing: Focus on Mesenchymal Stem Cells Life · 2023 · 3 citations
    26. Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing Stem Cells Translational Medicine · 2023
    27. Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis Stem cell reviews and reports · 2022 · 7 citations
    28. Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment Advanced Drug Delivery Reviews · 2023 · 90 citations
    29. THE MAGNITUDE OF SKIN DISEASE IN THE UNITED STATES Dermatologic Clinics · 2000 · 32 citations
    30. Fibroblasts in Diabetic Foot Ulcers International Journal of Molecular Sciences · 2024 · 33 citations