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GlossaryCHIR99021

small molecule inhibits GSK-3, aiding stem cell research

CHIR99021 is a small molecule inhibitor that specifically targets glycogen synthase kinase 3 (GSK-3). By inhibiting GSK-3, CHIR99021 can promote the self-renewal and pluripotency of stem cells, making it a valuable tool in stem cell research and regenerative medicine.

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In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

6 citations , May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

research Single-Cell Analysis of Murine Fibroblasts Identifies Neonatal to Adult Switching That Regulates Cardiomyocyte Maturation

112 citations , May 2020 in “Nature Communications”

Adult fibroblasts help heart cells mature and improve heart function.

research Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

26 citations , October 2023 in “Neuroscience Bulletin”

Stem cell therapy could help regenerate inner ear hair cells to treat hearing loss.

research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury

6 citations , February 2022 in “The journal of neuroscience/The Journal of neuroscience”

Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.

research Novel Protocol for the In Vitro Maintenance and Expansion of Adult Epidermal LGR5+ Stem Cells

December 2019 in “Reproduction Fertility and Development”

A new method helps grow skin stem cells better, which could improve skin grafts for burn victims.

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community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 2 years ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.