January 2026 in “Burns & Trauma” This study reported that NLRP3 plays complex roles in wound healing by initially promoting inflammation and delaying repair, but later enhancing structural restoration through distinct signaling pathways, highlighting its potential as a therapeutic target for controlling inflammation and regeneration phases.
74 citations
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September 2003 in “The Journal of Immunology” This study found that PKCα activation in transgenic mice induces keratinocyte apoptosis and mediates neutrophilic skin inflammation via different pathways, suggesting potential mechanisms for cutaneous inflammatory diseases.
October 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that applying the right mechanical stretch to skin can activate hair stem cells and promote hair regeneration through a pathway involving WNT, BMP-2, and M2 macrophages.
4 citations
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October 2024 in “Experimental Dermatology” In this study, researchers identified 173 differentially expressed genes in alopecia areata patients linked to immune and hair follicle pathways, constructed a regulatory network involving mRNA, miRNA, and lncRNA, and highlighted CD8A and FOXD2-AS1 as potential diagnostic markers and therapeutic targets.
1 citations
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January 2022 in “The Keio Journal of Medicine” This research describes how hair follicles regulate skin immune cells and how disruption in certain signaling pathways can lead to skin dysbiosis and inflammation; it also highlights the role of macrophages in protecting against cellulitis in mice.
